Epigenetic dysregulation in Epstein-Barr virus-associated gastric carcinoma: Disease and treatments

被引：52
作者：
Yau, Tung On [1 ,2 ]
Tang, Ceen-Ming [1 ,2 ,3 ]
Yu, Jun [1 ,2 ]
机构：
[1] Chinese Univ Hong Kong, Inst Digest Dis, Hong Kong, Hong Kong, Peoples R China
[2] Chinese Univ Hong Kong, LKS Inst Hlth Sci, Dept Med & Therapeut, State Key Lab Digest Dis, Hong Kong, Hong Kong, Peoples R China
[3] Univ Oxford, Dept Pharmacol, Oxford OX1 3QT, England
来源：
WORLD JOURNAL OF GASTROENTEROLOGY | 2014年 / 20卷 / 21期
关键词：
Epstein-Barr virus; Gastric carcinoma; Epigenetic dysregulation; Aberrant DNA methylation; Epigenetic therapies; HISTONE DEACETYLASE INHIBITORS; ISLAND METHYLATOR PHENOTYPE; DNA METHYLTRANSFERASE 1; MEMBRANE-PROTEIN; 2A; PROMOTER HYPERMETHYLATION; CANCER-CELLS; NASOPHARYNGEAL CARCINOMA; ABERRANT METHYLATION; SIGNALING PATHWAY; MICRORNA TARGETS;
D O I：
10.3748/wjg.v20.i21.6448
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC) comprises nearly 10% of gastric carcinoma cases worldwide. Recently, it was recognised to have unique clinicopathologic characteristics, including male predominance, lower rates of lymph node involvement, and better prognosis. EBVaGC is further characterised by abnormal hypermethylation of tumour suppressor gene promoter regions, causing down-regulation of their expression. In the present review, we critically discuss the role of EBV in gastric carcinogenesis, summarising the role of viral proteins and microRNAs with respect to aberrant methylation in EBVaGC. Given the role of epigenetic dysregulation in tumourigenesis, epigenetic modifiers may represent a novel therapeutic strategy. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
引用
收藏
页码：6448 / 6456
页数：9
相关论文
共 98 条
  • [1] Epstein-Barr virus-encoded microRNA miR-BART2 down-regulates the viral DNA polymerase BALF5
    Barth, Stephanie
    Pfuhl, Thorsten
    Mamiani, Alfredo
    Ehses, Claudia
    Roemer, Klaus
    Kremmer, Elisabeth
    Jaeker, Christoph
    Hoeck, Julia
    Meister, Gunter
    Graesser, Friedrich A.
    [J]. NUCLEIC ACIDS RESEARCH, 2008, 36 (02) : 666 - 675
  • [2] Thioester derivatives of the natural product psammaplin A as potent histone deacetylase inhibitors
    Baud, Matthias G. J.
    Leiser, Thomas
    Petrucci, Vanessa
    Gunaratnam, Mekala
    Neidle, Stephen
    Meyer-Almes, Franz-Josef
    Fuchter, Matthew J.
    [J]. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 2013, 9 : 81 - 88
  • [3] Concentrations of the DNA methyltransferase inhibitor 5-fluoro-2′-deoxycytidine (FdCyd) and its cytotoxic metabolites in plasma of patients treated with FdCyd and tetrahydrouridine (THU)
    Beumer, Jan H.
    Parise, Robert A.
    Newman, Edward M.
    Doroshow, James H.
    Synold, Timothy W.
    Lenz, Heinz-Josef
    Egorin, Merrill J.
    [J]. CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2008, 62 (02) : 363 - 368
  • [4] Effects of a novel DNA methyltransferase inhibitor zebularine on human breast cancer cells
    Billam, Madhavi
    Sobolewski, Michele D.
    Davidson, Nancy E.
    [J]. BREAST CANCER RESEARCH AND TREATMENT, 2010, 120 (03) : 581 - 592
  • [5] Blenk S, 2007, CANCER INFORM, V3, P399
  • [6] Anticancer activities of histone deacetylase inhibitors
    Bolden, Jessica E.
    Peart, Melissa J.
    Johnstone, Ricky W.
    [J]. NATURE REVIEWS DRUG DISCOVERY, 2006, 5 (09) : 769 - 784
  • [7] Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases
    Brueckner, B
    Boy, RG
    Siedlecki, P
    Musch, T
    Kliem, HC
    Zielenkiewicz, P
    Suhai, S
    Wiessler, M
    Lyko, F
    [J]. CANCER RESEARCH, 2005, 65 (14) : 6305 - 6311
  • [8] Case-case comparison of smoking and alcohol risk associations with Epstein-Barr virus-positive gastric cancer
    Camargo, M. Constanza
    Koriyama, Chihaya
    Matsuo, Keitaro
    Kim, Woo-Ho
    Herrera-Goepfert, Roberto
    Liao, Linda M.
    Yu, Jun
    Carrasquilla, Gabriel
    Sung, Joseph J. Y.
    Alvarado-Cabrero, Isabel
    Lissowska, Jolanta
    Meneses-Gonzalez, Fernando
    Yatabe, Yashushi
    Ding, Ti
    Hu, Nan
    Taylor, Philip R.
    Morgan, Douglas R.
    Gulley, Margaret L.
    Torres, Javier
    Akiba, Suminori
    Rabkin, Charles S.
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2014, 134 (04) : 948 - 953
  • [9] Improved survival of gastric cancer with tumour Epstein-Barr virus positivity: an international pooled analysis
    Camargo, M. Constanza
    Kim, Woo-Ho
    Chiaravalli, Anna Maria
    Kim, Kyoung-Mee
    Corvalan, Alejandro H.
    Matsuo, Keitaro
    Yu, Jun
    Sung, Joseph J. Y.
    Herrera-Goepfert, Roberto
    Meneses-Gonzalez, Fernando
    Kijima, Yuko
    Natsugoe, Shoji
    Liao, Linda M.
    Lissowska, Jolanta
    Kim, Sung
    Hu, Nan
    Gonzalez, Carlos A.
    Yatabe, Yashushi
    Koriyama, Chihaya
    Hewitt, Stephen M.
    Akiba, Suminori
    Gulley, Margaret L.
    Taylor, Philip R.
    Rabkin, Charles S.
    [J]. GUT, 2014, 63 (02) : 236 - 243
  • [10] Patterns of aberrant DNA hypermethylation in nasopharyngeal carcinoma in Tunisian patients
    Challouf, S.
    Ziadi, S.
    Zaghdoudi, R.
    Ksiaa, F.
    Ben Gacem, R.
    Trimeche, M.
    [J]. CLINICA CHIMICA ACTA, 2012, 413 (7-8) : 795 - 802
12345678910