Magnetic resonance spectroscopy study of glycine pathways in nonketotic hyperglycinemia

被引：33
作者：
Viola, A
Chabrol, B
Nicoli, F
Confort-Gouny, S
Viout, P
Cozzone, PJ
机构：
[1] Fac Med Timone, CRMBM, CNRS, UMR 6612, F-13005 Marseille, France
[2] CHU Timone, Neuropediat Serv, Marseille, France
来源：
PEDIATRIC RESEARCH | 2002年 / 52卷 / 02期
关键词：
D O I：
10.1023/01.PDR.0000019549.97278.EF
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Nonketotic hyperglycinemia is a life-threatening, disorder in neonates characterized by a deficiency of the glycine cleavage system. We report on four cases of the neonatal form of the disease, which were investigated by in vitro H-1 magnetic resonance spectroscopy of blood and cerebrospinal fluid, and in vivo H-1 magnetic resonance spectroscopy of brain. The existence of glycine disposal pathways leading to an increase in lactate in fluids and creatine in fluids and brain was demonstrated. This is the first observation of elevated creatine in brain in nonketotic hyperglycinemia. A recurrent decrease of glutamine and citrate was observed in cerebrospinal fluid, which might be related to abnormal glutamine metabolism in brain. Finally, the cerebral N-acetylaspartate to myo-inositol-glycine ratio was identified as a prognostic indicator of the disease.
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页数：9
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