A Short and Efficient Synthesis of the Selective H4 Receptor Agonist 4-Methylhistamine

被引：0

作者：

Rivara, Mirko ^{[1
]}

Zuliani, Valentina ^{[1
]}

Plazzi, Pier V. ^{[1
]}

Bordi, Fabrizio ^{[1
]}

机构：

[1] Univ Parma, Dipartimento Farmaceut, I-43100 Parma, Italy

来源：

LETTERS IN ORGANIC CHEMISTRY | 2009年 / 6卷 / 01期

关键词：

4-methylhistamine; histamine; H-4-receptor; n-butyllithium; H-4-agonist; yield; EOSINOPHIL CHEMOTAXIS; MEDIATES CHEMOTAXIS; HISTAMINE; IDENTIFICATION; DERIVATIVES; CELLS;

D O I：

10.2174/157017809787003223

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of the selective H-4 receptor agonist 4-methylhistamine is described. This approach can be used to prepare, without purification steps and in high yield, significant quantities of the product, useful as pharmacological tool to investigate the physiological roles of the histamine H-4 receptor.

引用

页码：88 / 89

页数：2

共 17 条

[11] Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation [J].