Cancer-associated fibroblasts: key determinants of tumor immunity and immunotherapy

被引：76
|
作者：
Barrett, Richard [1 ]
Pure, Ellen [1 ]
机构：
[1] Univ Penn, Philadelphia, PA 19104 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 2020年 / 64卷
关键词：
NATURAL-KILLER-CELLS; ACTIVATION PROTEIN; PANCREATIC-CANCER; SUPPRESSOR-CELLS; ANTITUMOR IMMUNITY; STROMAL CELLS; TGF-BETA; T-CELLS; RECEPTOR; GROWTH;
D O I：
10.1016/j.coi.2020.03.004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Immune-targeted approaches are rapidly changing the therapeutic landscape for cancer. In spite of that, most patients show resistance or acquire resistance to these therapies. Increasing work describing the tumor microenvironment (TME) has highlighted this space as one of the key determinants in tumor immune response and immunotherapeutic success. Frequently overlooked within this space, cancer-associated fibroblasts (CAFs) within the TME have surfaced as an important dictator of the tumor immune response. Herein, we review recent advances in defining the role of CAF-immune cell interactions in solid tumors and prospects for targeting stroma to overcome resistance to immunotherapy.
引用
收藏
页码：80 / 87
页数：8
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