Post-COVID-19 inflammatory syndrome manifesting as refractory status epilepticus

被引：52

作者：

Carroll, Elizabeth ^{[1
]}

Neumann, Henry ^{[2
]}

Aguero-Rosenfeld, Maria E. ^{[3
]}

Lighter, Jennifer ^{[4
]}

Czeisler, Barry M. ^{[1
,5
]}

Melmed, Kara ^{[1
,5
]}

Lewis, Ariane ^{[1
,5
]}

机构：

[1] NYU Langone Med Ctr, Dept Neurol, 530 First Ave,HCC 5A, New York, NY 10016 USA

[2] NYU Langone Med Ctr, Dept Med, New York, NY USA

[3] NYU Langone Med Ctr, Dept Pathol, New York, NY USA

[4] NYU Langone Med Ctr, Dept Pediat, New York, NY USA

[5] NYU Langone Med Ctr, Dept Neurosurg, New York, NY USA

来源：

EPILEPSIA | 2020年 / 61卷 / 10期

关键词：

COVID-19; inflammatory response; postinfectious; refractory status epilepticus; SARS-CoV-2; seizures; BLOOD;

D O I：

10.1111/epi.16683

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

There have been multiple descriptions of seizures during the acute infectious period in patients with COVID-19. However, there have been no reports of status epilepticus after recovery from COVID-19 infection. Herein, we discuss a patient with refractory status epilepticus 6 weeks after initial infection with COVID-19. Extensive workup demonstrated elevated inflammatory markers, recurrence of a positive nasopharyngeal SARS-CoV-2 polymerase chain reaction, and hippocampal atrophy. Postinfectious inflammation may have triggered refractory status epilepticus in a manner similar to the multisystemic inflammatory syndrome observed in children after COVID-19.

引用

页码：E135 / E139

页数：5

共 17 条

[1]

Achiriloaie A, 2016, CHILD NEUROL OPEN, V3

[2] Non-lesional status epilepticus in a patient with coronavirus disease 2019 [J].

Balloy, Gaelle ;

Leclair-Visonneau, Laurene ;

Pereon, Yann ;

Magot, Armelle ;

Peyre, Arnaud ;

Mahe, Pierre-Joachim ;

Derkinderen, Pascal .

CLINICAL NEUROPHYSIOLOGY, 2020, 131 (08) :2059-2061

[3] Encephalopathy and Encephalitis Associated with Cerebrospinal Fluid Cytokine Alterations and Coronavirus Disease, Atlanta, Georgia, USA, 2020 [J].

Benameur, Karima ;

Agarwal, Ankita ;

Auld, Sara C. ;

Butters, Matthew P. ;

Webster, Andrew S. ;

Ozturk, Tugba ;

Howell, J. Christina ;

Bassit, Leda C. ;

Velasquez, Alvaro ;

Schinazi, Raymond F. ;

Mullins, Mark E. ;

Hu, William T. .

EMERGING INFECTIOUS DISEASES, 2020, 26 (09) :2016-2021

[4]

Centers for Disease Control and Prevention, DURATION ISOLATION P

[5] A Case Series of Guillain-Barre Syndrome After COVID-19 Infection in New York [J].

Chan, Monica ;

Han, Steve C. ;

Kelly, Sean ;

Tamimi, Michael ;

Giglio, Brandon ;

Lewis, Ariane .

NEUROLOGY-CLINICAL PRACTICE, 2021, 11 (04) :E576-E578

[6] Hippocampal atrophy may be a predictor of seizures in Alzheimer's disease [J].

Dhikav, Vikas ;

Anand, Kuljeet .

MEDICAL HYPOTHESES, 2007, 69 (01) :234-235

[7] IMMUNOGLOBULIN ABNORMALITIES IN CEREBROSPINAL-FLUID AND BLOOD IN CHILDREN WITH FEBRILE SEIZURES [J].

EEGOLOFSSON, O ;

WIGERTZ, A ;

LINK, H .

NEUROPEDIATRICS, 1982, 13 (01) :39-41

[8] New onset acute symptomatic seizure and risk factors in coronavirus disease 2019: A retrospective multicenter study [J].

Lu, Lu ;

Xiong, Weixi ;

Liu, Dan ;

Liu, Jing ;

Yang, Dan ;

Li, Nian ;

Mu, Jie ;

Guo, Jian ;

Li, Weimin ;

Wang, Gang ;

Gao, Hui ;

Zhang, Yingying ;

Lin, Mintao ;

Chen, Lei ;

Shen, Sisi ;

Zhang, Hesheng ;

Sander, Josemir W. ;

Luo, Jianfei ;

Chen, Shengli ;

Zhou, Dong .

EPILEPSIA, 2020, 61 (06) :E49-E53

[9]

Lynch DR, 2018, ADV PHARMACOL, V82, P235, DOI 10.1016/bs.apha.2017.08.005

[10] Acute disseminated encephalomyelitis after SARS-CoV-2 infection [J].

Novi, Giovanni ;

Rossi, Tommaso ;

Pedemonte, Enrico ;

Saitta, Laura ;

Rolla, Claudia ;

Roccatagliata, Luca ;

Inglese, Matilde ;

Farinini, Daniele .

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION, 2020, 7 (05)

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