Childhood Onset Schizophrenia and Early Onset Schizophrenia Spectrum Disorders

被引:92
作者
Driver, David I. [1 ]
Gogtay, Nitin [1 ]
Rapoport, Judith L. [1 ]
机构
[1] NIMH, Child Psychiat Branch, NIH, Bethesda, MD 20892 USA
关键词
Schizophrenia; Childhood onset schizophrenia; Childhood psychosis; CORTICAL BRAIN-DEVELOPMENT; TREATMENT DELAY; GRAY-MATTER; 1ST-EPISODE PSYCHOSIS; PREMORBID ADJUSTMENT; EMOTIONAL DISORDERS; BORDERLINE SYNDROME; CHILDREN; HALLUCINATIONS; MULTIPLE;
D O I
10.1016/j.chc.2013.04.001
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
The clinical severity, impact on development, and poor prognosis of childhood onset schizophrenia may represent a more homogeneous group. Positive symptoms in children are necessary for the diagnosis and hallucinations are more often multimodal. In healthy children and children with a variety of other psychiatric illnesses, hallucinations are not uncommon and diagnosis should not be based on these alone. Childhood onset schizophrenia is an extraordinarily rare illness that is poorly understood but seems continuous with the adult onset disorder. Once a diagnosis is affirmed, aggressive medication treatment combined with family education and individual counseling may defer further deterioration.
引用
收藏
页码:539 / +
页数:18
相关论文
共 101 条
  • [51] Schizophrenia, "just the facts": What we know in 2008 Part 3: Neurobiology
    Keshavan, Matcheri S.
    Tandon, Rajiv
    Boutros, Nash N.
    Nasrallah, Henry A.
    [J]. SCHIZOPHRENIA RESEARCH, 2008, 106 (2-3) : 89 - 107
  • [52] Neurobiology of early psychosis
    Keshavan, MS
    Berger, G
    Zipursky, RB
    Wood, SJ
    Pantelis, C
    [J]. BRITISH JOURNAL OF PSYCHIATRY, 2005, 187 : S8 - S18
  • [53] Genetic Neuropathology of Schizophrenia: New Approaches to an Old Question and New Uses for Postmortem Human Brains
    Kleinman, Joel E.
    Law, Amanda J.
    Lipska, Barbara K.
    Hyde, Thomas M.
    Ellis, Justin K.
    Harrison, Paul J.
    Weinberger, Daniel R.
    [J]. BIOLOGICAL PSYCHIATRY, 2011, 69 (02) : 140 - 145
  • [55] Multidimensionally impaired disorder: Is it a variant of very early-onset schizophrenia?
    Kumra, S
    Jacobsen, LK
    Lenane, M
    Zahn, TP
    Wiggs, E
    Alaghband-Rad, J
    Castellanos, FX
    Frazier, JA
    McKenna, K
    Gordon, CT
    Smith, A
    Hamburger, S
    Rapoport, JL
    [J]. JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 1998, 37 (01) : 91 - 99
  • [56] Kumra S, 1999, AM J PSYCHIAT, V156, P1065
  • [57] Lambert Timothy J R, 2003, Med J Aust, V178, pS67
  • [58] Measurement and reporting of the duration of untreated psychosis
    Large, Matthew
    Nielssen, Olav
    Slade, Tim
    Harris, Anthony
    [J]. EARLY INTERVENTION IN PSYCHIATRY, 2008, 2 (04) : 201 - 211
  • [59] Brain abnormality in schizophrenia - A systematic and quantitative review of volumetric magnetic resonance imaging studies
    Lawrie, SM
    Abukmeil, SS
    [J]. BRITISH JOURNAL OF PSYCHIATRY, 1998, 172 : 110 - 120
  • [60] Neuroplasticity of neocortical circuits in schizophrenia
    Lewis, David A.
    Gonzalez-Burgos, Guillermo
    [J]. NEUROPSYCHOPHARMACOLOGY, 2008, 33 (01) : 141 - 165