Proteoglycans and Glycosaminoglycans Improve Toughness of Biocompatible Double Network Hydrogels

被引：180

作者：

Zhao, Yu ^{[2
]}

Nakajima, Tasuku ^{[1
]}

Yang, Jing Jing ^{[1
]}

Kurokawa, Takayuki ^{[1
]}

Liu, Jian ^{[3
]}

Lu, Jishun ^{[4
]}

Mizumoto, Shuji ^{[4
]}

Sugahara, Kazuyuki ^{[4
]}

Kitamura, Nobuto ^{[5
]}

Yasuda, Kazunori ^{[5
]}

Daniels, A. U. D. ^{[6
]}

Gong, Jian Ping ^{[1
]}

机构：

[1] Hokkaido Univ, Fac Adv Life Sci, Lab Soft & Wet Matter, Kita Ku, Sapporo, Hokkaido 0600810, Japan

[2] Hokkaido Univ, Grad Sch Life Sci, Lab Soft & Wet Matter, Kita Ku, Sapporo, Hokkaido 0600810, Japan

[3] Hokkaido Univ, Grad Sch Sci, Lab Soft & Wet Matter, Kita Ku, Sapporo, Hokkaido 0600810, Japan

[4] Hokkaido Univ, Fac Adv Life Sci, Lab Proteoglycan Signaling & Therapeut, Kita Ku, Sapporo, Hokkaido 0010021, Japan

[5] Hokkaido Univ, Dept Sports Med & Joint Surg, Grad Sch Med, Kita Ku, Sapporo, Hokkaido 0600821, Japan

[6] Univ Basel, Fac Med, Biomech & Calorimetry Ctr Basel, CH-4056 Basel, Switzerland

来源：

ADVANCED MATERIALS | 2014年 / 26卷 / 03期

基金：

日本学术振兴会; 日本科学技术振兴机构;

关键词：

hydrogels; proteoglycans; glycosaminoglycans; toughness; biocompatibility; BEHAVIOR; CELLS; GELS;

D O I：

10.1002/adma.201303387

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Based on the molecular stent concept, a series of tough double-network hydrogels (St-DN gels) made from the components of proteoglycan aggregates - chondroitin sulfate proteoglycans (1), chondroitin sulfate (2), and sodium hyaluronate (3) - are successfully developed in combination with a neutral biocompatible polymer. This work demonstrates a promising method to create biopolymer-based tough hydrogels for biomedical applications. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：436 / 442

页数：7

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