Prenatal Stress and Risk of Spontaneous Abortion

被引：41

作者：

Wainstock, Tamar ^{[1
]}

Lerner-Geva, Liat ^{[3
,4
]}

Glasser, Saralee ^{[3
]}

Shoham-Vardi, Ilana ^{[1
]}

Anteby, Eyal Y. ^{[2
]}

机构：

[1] Ben Gurion Univ Negev, Fac Hlth Sci, Dept Epidemiol, IL-84105 Beer Sheva, Israel

[2] Barzilai Govt Hosp, Dept Obstet & Gynecol, Ashqelon, Israel

[3] Gertner Inst Epidemiol & Hlth Policy Res, Women & Childrens Hlth Res Unit, Tel Hashomer, Israel

[4] Tel Aviv Univ, Sackler Fac Med, Sch Publ Hlth, IL-69978 Tel Aviv, Israel

来源：

PSYCHOSOMATIC MEDICINE | 2013年 / 75卷 / 03期

关键词：

prenatal maternal stress; spontaneous abortion; LOW-BIRTH-WEIGHT; SPONTANEOUS PRETERM BIRTH; PSYCHOSOCIAL PREDICTORS; PSYCHOLOGICAL DISTRESS; MATERNAL EXPOSURE; CARE UTILIZATION; LIFE EVENTS; CIVIL-WAR; PREGNANCY; CORTISOL;

D O I：

10.1097/PSY.0b013e318280f5f3

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective: The aim of this study was to evaluate the association between exposure to life-threatening rocket attacks and spontaneous abortions (SAs). Study Design: This is a historical cohort study comparing 1345 pregnancies of female residents of a town exposed to rocket attacks with 2143 pregnancies of female residents of an unexposed town. Demographic and medical data were obtained from hospital records and exposure information from official local databases. Intensity of exposure was calculated for preconception and pregnancy periods. Results: Compared with unexposed group, women in the exposed group had higher rates of SA (6.9% versus 4.7%, adjusted odds ratio = 1.59, 95% confidence interval = 1.17-2.2, p = .003). Intensity of preconception and pregnancy exposure were nonlinearly associated with SA risk; both the highest and the lowest quintiles of exposure were associated with increased risk of SA. Conclusions: Stress during preconception and pregnancy was associated with increased risk of SA.

引用

页码：228 / 235

页数：8

共 59 条

[21] Maternal plasma corticotropin-releasing hormone associated with stress at 20 weeks' gestation in pregnancies ending in preterm delivery [J].