Intracellular pH-activated PEG-b-PDPA wormlike micelles for hydrophobic drug delivery

被引：55
|
作者：
Yu, Haijun [1 ]
Xu, Zhiai [2 ]
Wang, Dangge [1 ]
Chen, Xianzhi [1 ]
Zhang, Zhiwen [1 ]
Yin, Qi [1 ]
Li, Yaping [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China
[2] E China Normal Univ, Dept Chem, Shanghai 200241, Peoples R China
来源：
POLYMER CHEMISTRY | 2013年 / 4卷 / 19期
基金：
中国国家自然科学基金;
关键词：
NILE-RED; NANOPARTICLES; CANCER; COPOLYMERS; SYSTEMS; SIRNA;
D O I：
10.1039/c3py00849e
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Wormlike micelles with intracellular pH-activating properties were developed. The micelles remained in a "silent" state at physiological pH conditions (i.e. pH 7.4), but were activated in the acidic microenvironment of endocytic vesicles. The wormlike micelles could be employed as nanovectors for the intracellular delivery of hydrophobic drugs for cancer therapy.
引用
收藏
页码：5052 / 5055
页数：4
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