How the microenvironment wires the natural history of chronic lymphocytic leukemia

被引：72

作者：

Caligaris-Cappio, Federico ^{[1
,2
]}

Bertilaccio, Maria T. S. ^{[1
]}

Scielzo, Cristina ^{[1
]}

机构：

[1] Ist Sci San Raffaele, Div Mol Oncol, Unit Lymphoid Malignancies, I-20132 Milan, Italy

[2] Univ Vita Salute San Raffaele, I-20132 Milan, Italy

来源：

SEMINARS IN CANCER BIOLOGY | 2014年 / 24卷

关键词：

Chronic lymphocytic leukemia; Microenviroment; Mouse models; Cytoskeleton; TRANSGENIC MOUSE MODEL; TOLL-LIKE RECEPTORS; THERAPEUTIC TARGET; CELL; ACTIVATION; TUMOR; EXPRESSION; APOPTOSIS; HS1; CLL;

D O I：

10.1016/j.semcancer.2013.06.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The investigation on the mechanisms that govern the development and progression of cancer is constantly swaying between "seed" and "soil". Chronic lymphocytic leukemia (CLL) makes no exception. Its natural history, including response to treatment and drug resistance, is determined both by causal and influential genes and by the relationships that leukemic cells entertain with their supportive microenvironments. Therefore dissecting the role of microenvironment may provide new strategies of diagnosis and treatment. CLL, though phenotypically homogeneous, is clinically heterogeneous and despite major therapeutic advances remains incurable. Conceivably the host of new non-genotoxic drugs that operate at the forefront between tumor cells and their milieu will modify the present therapeutic perspective by re-shaping the tumor cell/microenvironment cross talk. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：43 / 48

页数：6

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