SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF ISONIAZID CONDENSED WITH CARBOHYDRATE DERIVATIVES

被引：14

作者：

Cardoso, Silvia H. ^{[1
]}

de Assis, Joao Vitor ^{[1
]}

de Almeida, Mauro V. ^{[1
]}

Lourenco, Maria Cristina S. ^{[2
]}

Vicente, Felipe R. C. ^{[2
]}

de Souza, Marcus V. N. ^{[2
]}

机构：

[1] Univ Fed Juiz de Fora, Inst Ciencias Exatas, Dept Quim, BR-36036330 Juiz De Fora, MG, Brazil

[2] Fundacao Oswaldo Cruz, BR-21041250 Rio De Janeiro, Brazil

来源：

QUIMICA NOVA | 2009年 / 32卷 / 06期

关键词：

isoniazid analogs; carbohydrates; antimycobacterial activity; ALAMAR BLUE ASSAY; MYCOBACTERIUM-TUBERCULOSIS; SUSCEPTIBILITY; FUTURE; AGENTS; TARGET; DRUGS;

D O I：

10.1590/S0100-40422009000600038

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of 13 compounds analogous of isoniazid condensed with carbohydrate was synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H(37)Rv using Alamar Blue susceptibility test and the activity expressed as the minimum inhibitory concentration (MIC90) in mu g/mL. Several compounds exhibited antitubercular activity (0.31-3.12 mu g/mL) when compared with first line drugs such as isoniazid (INH) and rifampicin (RIP) and could be a good starting point to develop new compounds against tuberculosis.

引用

页码：1557 / 1560

页数：4

共 50 条

[41] Oxidative Cyclization of Isoniazid with Fluoroquinolones: Synthesis, Antibacterial and Antitubercular Activity of New 2,5-disubstituted-1,3,4-Oxadiazoles [J].

Khan, Shah Alam ;

Ahuja, Priyanka ;

Husain, Asif .

JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 2017, 64 (08) :918-924

[42] Structure elaboration of isoniazid: synthesis, in silico molecular docking and antimycobacterial activity of isoniazid-pyrimidine conjugates [J].

Kaur, Hardeep ;

Singh, Lovepreet ;

Chibale, Kelly ;

Singh, Kamaljit .

MOLECULAR DIVERSITY, 2020, 24 (04) :949-955

[43] Design and synthesis of novel s-triazine based coumarin, quinoline, morpholine and isoniazid derivatives and their antitubercular and antimicrobial evaluation [J].

Mahyavanshi, Jyotindra ;

Shrivastava, Vijay ;

Patel, Shraddha ;

Pandya, Jayesh .

INDIAN JOURNAL OF CHEMISTRY, 2022, 61 (03) :285-292

[44] Synthesis and antitubercular evaluation of new fluoroquinolone derivatives coupled with carbohydrates [J].

Saraiva, Mauricio F. ;

de Souza, Marcus V. N. ;

Dau, Marie E. Tran Huu ;

Araujo, Debora P. ;

de Carvalho, Gustavo S. G. ;

de Almeida, Mauro V. .

CARBOHYDRATE RESEARCH, 2010, 345 (06) :761-767

[45] New lipophilic isoniazid derivatives and their 1,3,4-oxadiazole analogues: Synthesis, antimycobacterial activity and investigation of their mechanism of action [J].

Vosatka, Rudolf ;

Kratkj, Martin ;

Svarcova, Marketa ;

Janousek, Jiri ;

Stolarikova, Jirina ;

Madacki, Jan ;

Huszar, Stanislav ;

Mikusova, Katarina ;

Kordulakova, Jana ;

Trejtnar, Frantisek ;

Vinsova, Jarmila .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 151 :824-835

[46] Isoniazid Analogs and Their Biological Activities as Antitubercular Agents (A Review) [J].

Alghamdi, S. ;

Qusty, N. F. ;

Atwah, B. ;

Alhindi, Z. ;

Alatawy, R. ;

Verma, S. ;

Asif, M. .

RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2024, 94 (08) :2101-2141

[47] Synthesis and in vitro antitubercular activity of pyridine analouges against the resistant Mycobacterium tuberculosis [J].

Patel, Harun ;

Chaudhari, Kavita ;

Jain, Pritam ;

Surana, Sanjay .

BIOORGANIC CHEMISTRY, 2020, 102

[48] Design, Synthesis, Docking and Biological Study of Pyrazole-3,5-diamine Derivatives with Potent Antitubercular Activity [J].

Pawar, Devidas C. ;

V. Gaikwad, Sunil ;

Kamble, Sonali S. ;

Gavhane, Priya D. ;

V. Gaikwad, Milind ;

Dawane, Bhaskar S. .

CHEMICAL METHODOLOGIES, 2022, 6 (09) :677-690

[49] Synthesis of Novel Azetidinone Derivatives as Antitubercular Agents [J].

Himaja, M. ;

Karigar, Asif ;

Ramana, M. V. ;

Munirajasekhar, D. ;

Sikarwar, Mukesh S. .

LETTERS IN DRUG DESIGN & DISCOVERY, 2012, 9 (06) :611-617

[50] Synthesis of new spirooxindole derivatives through 1,3-dipolar cycloaddition of azomethine ylides and their antitubercular activity [J].

Rouatbi, Fadwa ;

Askri, Moheddine ;

Nana, Frederic ;

Kirsch, Gilbert ;

Sriram, Dharmarajan ;

Yogeeswari, Perumal .

TETRAHEDRON LETTERS, 2016, 57 (02) :163-167

← 1 2 3 4 5 →