SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF ISONIAZID CONDENSED WITH CARBOHYDRATE DERIVATIVES

被引：14
作者：
Cardoso, Silvia H. [1 ]
de Assis, Joao Vitor [1 ]
de Almeida, Mauro V. [1 ]
Lourenco, Maria Cristina S. [2 ]
Vicente, Felipe R. C. [2 ]
de Souza, Marcus V. N. [2 ]
机构：
[1] Univ Fed Juiz de Fora, Inst Ciencias Exatas, Dept Quim, BR-36036330 Juiz De Fora, MG, Brazil
[2] Fundacao Oswaldo Cruz, BR-21041250 Rio De Janeiro, Brazil
来源：
QUIMICA NOVA | 2009年 / 32卷 / 06期
关键词：
isoniazid analogs; carbohydrates; antimycobacterial activity; ALAMAR BLUE ASSAY; MYCOBACTERIUM-TUBERCULOSIS; SUSCEPTIBILITY; FUTURE; AGENTS; TARGET; DRUGS;
D O I：
10.1590/S0100-40422009000600038
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of 13 compounds analogous of isoniazid condensed with carbohydrate was synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H(37)Rv using Alamar Blue susceptibility test and the activity expressed as the minimum inhibitory concentration (MIC90) in mu g/mL. Several compounds exhibited antitubercular activity (0.31-3.12 mu g/mL) when compared with first line drugs such as isoniazid (INH) and rifampicin (RIP) and could be a good starting point to develop new compounds against tuberculosis.
引用
收藏
页码：1557 / 1560
页数：4
相关论文
共 50 条
  • [21] Synthesis and antitubercular activity of heterocycle substituted diphenyl ether derivatives
    Kini, Suvarna G.
    Bhat, Anilchandra
    Pan, Zhiqiang
    Dayan, Franck E.
    JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2010, 25 (05) : 730 - 736
  • [22] Synthesis and antitubercular activity of new mefloquine-oxazolidine derivatives
    Goncalves, Raoni S. B.
    Kaiser, Carlos R.
    Lourenco, Maria C. S.
    de Souza, Marcus V. N.
    Wardell, James L.
    Wardell, Solange M. S. V.
    da Silva, Adilson D.
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (12) : 6095 - 6100
  • [23] Hydrazide-Hydrazone Derivatives and Their Antitubercular Activity
    Thorat, B. R.
    Mali, S. N.
    Shah, Umang
    Garg, A.
    Agrawal, R.
    Arvindekar, S. A.
    Cruz, J. N.
    de Oliveira, M. Santana
    Shaik, A. B.
    Lokesh, B. V. S.
    RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2025, 51 (01) : 35 - 52
  • [24] Quinazoline derivatives with antitubercular activity
    Kunes, J
    Bazant, J
    Pour, M
    Waisser, K
    Slosárek, M
    Janota, J
    FARMACO, 2000, 55 (11-12): : 725 - 729
  • [25] New INH-pyrazole analogs: Design, synthesis and evaluation of antitubercular and antibacterial activity
    Nayak, Nagabhushana
    Ramprasad, Jurupula
    Dalimba, Udayakumar
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 25 (23) : 5540 - 5545
  • [26] Juglone derivatives as antitubercular agents: A rationale for the activity profile
    Sharma, Smriti
    Sharma, Brij K.
    Prabhakar, Yenamandral S.
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (07) : 2847 - 2853
  • [27] STUDIES ON THE DESIGN, SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF SOME NEW QUINAZOLINONE DERIVATIVES
    Akram, Md
    Sayeed, Abdul
    Salaam, Syed Shah Abdus
    INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2018, 5 (03): : 1915 - 1925
  • [28] Design, Synthesis and Anti-Tubercular Activity of Isoniazid Derivatives
    Imran, Mohd
    Bawadekji, Abdulhakim
    Al Ali, Mouhanad
    RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES, 2018, 9 (05): : 2413 - 2419
  • [29] Synthesis and Antimycobacterial Activity of Isoniazid Derivatives Tethered with Aliphatic Amines
    Pflegr, Vaclav
    Stolarikova, Jirina
    Vinsova, Jarmila
    Kratky, Martin
    CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2022, 22 (32) : 2695 - 2706
  • [30] Phenylisoxazole-3/5-Carbaldehyde Isonicotinylhydrazone Derivatives: Synthesis, Characterization, and Antitubercular Activity
    Carrasco, Fernando
    Hernandez, Wilfredo
    Chupayo, Oscar
    Sheen, Patricia
    Zimic, Mirko
    Coronel, Jorge
    Alvarez, Celedonio M.
    Ferrero, Sergio
    Oramas-Royo, Sandra
    Spodine, Evgenia
    Rodilla, Jesus M.
    Davalos, Juan Z.
    JOURNAL OF CHEMISTRY, 2021, 2021
12345