Aggreganoids A-F, Carbon-Bridged Sesquiterpenoid Dimers and Trimers from Lindera aggregata

被引:33
作者
Liu, Xin [1 ]
Yang, Ji [1 ]
Fu, Jing [1 ]
Yao, Xiao-Jun [1 ]
Wang, Jing-Rong [1 ]
Liu, Liang [1 ]
Jiang, Zhi-Hong [1 ]
Zhu, Guo-Yuan [1 ]
机构
[1] Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Macau Inst Appl Res Med & Hlth, Macau, Peoples R China
关键词
ROOT TUBERS; LACTONES; STRYCHNIFOLIA;
D O I
10.1021/acs.orglett.9b02166
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Six oligomeric sesquiterpenoids, aggreganoids A-F (1-6), were isolated from Lindera aggregata. Aggreganoid A (1) and B (2) are two unprecedented methine- or methylene-bridged sesquiterpenoid trimers possessing a unique C-46 skeleton. Aggreganoids C-F (3-6) are the first examples of carbon-bridged disesquiterpenoids with a C-33 or C-31 skeleton in the plant kingdom. Their structures and absolute configurations were elucidated by using spectroscopic methods and electronic circular dichroism calculations. A plausible biosynthetic pathway of these compounds was also proposed.
引用
收藏
页码:5753 / 5756
页数:4
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