miRNAs in immune responses to Mycobacterium tuberculosis infection

被引：64

作者：

Yang, Tianshu ^{[1
,2
]}

Ge, Baoxue ^{[1
,2
]}

机构：

[1] Tongji Univ, Shanghai Pulm Hosp, Shanghai Key Lab TB, Sch Med, Shanghai, Peoples R China

[2] Tongji Univ Med, Dept Microbiol & Immunol, Shanghai, Peoples R China

来源：

CANCER LETTERS | 2018年 / 431卷

基金：

中国国家自然科学基金;

关键词：

microRNA; Immune response; Macrophages; Tuberculosis; SINGLE NUCLEOTIDE POLYMORPHISMS; PULMONARY TUBERCULOSIS; MICRORNA EXPRESSION; ACTIVE TUBERCULOSIS; DENDRITIC CELLS; CORRESPONDING MICRORNAS; ANTIMICROBIAL RESPONSES; INFLAMMATORY RESPONSES; CIRCULATING MICRORNAS; GENETIC ASSOCIATIONS;

D O I：

10.1016/j.canlet.2018.05.028

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tuberculosis (TB) is one of the most fatal infectious diseases, affecting one third of the world's population. The causative agent, Mycobacteriwn tuberculosis (Mtb), has a well-established ability to circumvent the host's immune system for its long-term intracellular survival. MicroRNAs (miRNAs) are crucial post-transcriptional regulators of immune response. They act by negatively regulating the expression levels of important genes in both innate and adaptive immunity. It has been established in recent studies that the host immune response against Mtb is regulated by many miRNAs, most of which are induced by Mtb infection. Moreover, differential expression of miRNA in tuberculosis (TB) patients may help distinguish between TB patients and healthy individuals or latent TB. In this review, we present the recent advancements on the miRNA regulation of the host responses against Mtb infection, as well as the potential of miRNAs to as biomarkers for TB diagnosis.

引用

页码：22 / 30

页数：9

共 120 条

[21] Multidrug-resistant tuberculosis around the world: what progress has been made? [J].

Falzon, Dennis ;

Mirzayev, Fuad ;

Wares, Fraser ;

Baena, Ines Garcia ;

Zignol, Matteo ;

Nguyen Linh ;

Weyer, Karin ;

Jaramillo, Ernesto ;

Floyd, Katherine ;

Raviglione, Mario .

EUROPEAN RESPIRATORY JOURNAL, 2015, 45 (01) :150-160

[22] MicroRNA-206 regulates the secretion of inflammatory cytokines and MMP9 expression by targeting TIMP3 in Mycobacterium tuberculosis-infected THP-1 human macrophages [J].

Fu, Xiangdong ;

Zeng, Lihong ;

Liu, Zhi ;

Ke, Xue ;

Lei, Lin ;

Li, Guobao .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2016, 477 (02) :167-173

[23] Deregulated microRNAs in CD4+ T cells from individuals with latent tuberculosis versus active tuberculosis [J].

Fu, Yurong ;

Yi, Zhengjun ;

Li, Jianhua ;

Li, Ruifang .

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2014, 18 (03) :503-513

[24] Circulating MicroRNAs in Patients with Active Pulmonary Tuberculosis [J].

Fu, Yurong ;

Yi, Zhengjun ;

Wu, Xiaoyan ;

Li, Jianhua ;

Xu, Fuliang .

JOURNAL OF CLINICAL MICROBIOLOGY, 2011, 49 (12) :4246-4251

[25] Alteration of human macrophages microRNA expression profile upon infection with Mycobacterium tuberculosis [J].

Furci, Lucinda ;

Schena, Elisa ;

Miotto, Paolo ;

Cirillo, Daniela M. .

INTERNATIONAL JOURNAL OF MYCOBACTERIOLOGY, 2013, 2 (03) :128-134

[26] Cell wall-associated alpha-glucan is instrumental for Mycobacterium tuberculosis to block CD1 molecule expression and disable the function of dendritic cell derived from infected monocyte [J].

Gagliardi, Maria Cristina ;

Lemassu, Anne ;

Teloni, Raffaela ;

Mariotti, Sabrina ;

Sargentini, Valeria ;

Pardini, Manuela ;

Daffe, Mamadou ;

Nisini, Roberto .

CELLULAR MICROBIOLOGY, 2007, 9 (08) :2081-2092

[27] MiR-23a-5p modulates mycobacterial survival and autophagy during mycobacterium tuberculosis infection through TLR2/MyD88/NF-κB pathway by targeting TLR2 [J].

Gu, Xing ;

Gao, Yan ;

Mu, De-Guang ;

Fu, En-Qing .

EXPERIMENTAL CELL RESEARCH, 2017, 354 (02) :71-77

[28] microRNA-20a Inhibits Autophagic Process by Targeting ATG7 and ATG16L1 and Favors Mycobacterial Survival in Macrophage Cells [J].

Guo, Le ;

Zhao, Jin ;

Qu, Yuliang ;

Yin, Runting ;

Gao, Qian ;

Ding, Shuqin ;

Zhang, Ying ;

Wei, Jun ;

Xu, Guangxian .

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2016, 6

[29] Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs [J].

Hergenreider, Eduard ;

Heydt, Susanne ;

Treguer, Karine ;

Boettger, Thomas ;

Horrevoets, Anton J. G. ;

Zeiher, Andreas M. ;

Scheffer, Margot P. ;

Frangakis, Achilleas S. ;

Yin, Xiaoke ;

Mayr, Manuel ;

Braun, Thomas ;

Urbich, Carmen ;

Boon, Reinier A. ;

Dimmeler, Stefanie .

NATURE CELL BIOLOGY, 2012, 14 (03) :249-+

[30] miR-155 is upregulated in patients with active tuberculosis and inhibits apoptosis of monocytes by targeting FOXO3 [J].

Huang, Jian ;

Jiao, Junhua ;

Xu, Weihua ;

Zhao, Huayang ;

Zhang, Chunxiao ;

Shi, Yan ;

Xiao, Zhijian .

MOLECULAR MEDICINE REPORTS, 2015, 12 (05) :7102-7108

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