Isolated diaphragmatic metastasis from periosteal osteosarcoma of the humerus: a case report

被引：2

作者：

Zhao, Luo ^{[1
]}

Qin, Yingzhi ^{[1
]}

Ma, Dongjie ^{[1
]}

Wang, Wenze ^{[2
]}

Li, Shanqing ^{[1
]}

Liu, Hongsheng ^{[1
]}

机构：

[1] CAMS & PUMC, Peking Union Med Coll Hosp, Dept Thorac Surg, 1 Shuaifuyuan, Beijing 100730, Peoples R China

[2] CAMS & PUMC, Peking Union Med Coll Hosp, Dept Pathol, Beijing 100730, Peoples R China

来源：

JOURNAL OF CARDIOTHORACIC SURGERY | 2020年 / 15卷 / 01期

关键词：

Periosteal osteosarcoma; Diaphragm metastasis; Gene mutation; Case report;

D O I：

10.1186/s13019-020-01103-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Isolated diaphragmatic metastasis is rarely associated with periosteal osteosarcoma. Case presentation: A 24-year-old female patient was found to have periosteal osteosarcoma of the right humerus 11 years ago. Computed tomography showed a mass in her left chest in 2018, and thoracotomy was performed to remove the tumour. The tumour showed the same characteristics as the original periosteal osteosarcoma. Genetic analysis of the tumour sample showed a TP53 point mutation and CCNE1 gene copy number variants. Conclusions: We believe this is the first case report of haematogenous metastasis to the diaphragm of periosteal osteosarcoma, and an investigation of the genetic factors may help to unravel the underlying cause of periosteal osteosarcoma.

引用

页数：3

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