Aberrant NEAT1 promotes migration in endometrial cancer and as marker of poor prognosis

NEAT1 shares homology with NEAT2 (also known as MALAT-1), which is a well characterized lncRNA that promotes the migration of malignant cells. However, the function of NEAT1 in endometrial cancer (EC) remains unknown. Here, we investigated the NEAT1 expression levels in EC tissue using ISH. The median score of NEAT1 in EC tissues was used as a cutoff value to divided the patient cohort into 2 groups, the high expression and low expression groups for further analysis of the correlation between the NEAT1 levels and the clinical characteristics of EC. Moreover, we silenced NEAT1 in EC cells, and measured cell mobility using the wound healing and transwell assays. We found that the level of NEAT1 was a marker of poor prognosis of EC; elevated NEAT1 levels corresponded to a lower OS and were closely related with metastasis. Knocking down NEAT1 in EC cells significantly inhibited cell mobility. Consequently, our findings suggest that NEAT1 promotes migration and may serve as a predictive marker for EC patients.