3D chromatin architecture and epigenetic regulation in cancer stem cells

被引：34
作者：
Feng, Yuliang [1 ]
Liu, Xingguo [2 ,3 ,4 ]
Pauklin, Siim [1 ]
机构：
[1] Univ Oxford, Botnar Res Ctr, Nuffield Dept Orthopaed, Rheumatol & Musculoskeletal Sci Old Rd, Oxford OX3 7LD, England
[2] Chinese Acad Sci, Joint Sch Life Sci, Hefei Inst Stem Cell & Regenerat Med,CAS Key Lab, Guangzhou Inst Biomed & Hlth,Guangzhou Regenerat, Guangzhou 510530, Peoples R China
[3] Guangzhou Med Univ, Guangzhou 510530, Peoples R China
[4] Chinese Acad Sci, Inst Stem Cell & Regenerat, Guangzhou Inst Biomed & Hlth, Guangdong Prov Key Lab Stem Cell & Regenerat Med, Guangzhou 510530, Peoples R China
来源：
PROTEIN & CELL | 2021年 / 12卷 / 06期
关键词：
chromatin architecture; 3D chromatin topology; epigenetics; tumorigenesis; cancer stem cells; pluripotent stem cells;
D O I：
10.1007/s13238-020-00819-2
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Dedifferentiation of cell identity to a progenitor-like or stem cell-like state with increased cellular plasticity is frequently observed in cancer formation. During this process, a subpopulation of cells in tumours acquires a stem cell-like state partially resembling to naturally occurring pluripotent stem cells that are temporarily present during early embryogenesis. Such characteristics allow these cancer stem cells (CSCs) to give rise to the whole tumour with its entire cellular heterogeneity and thereby support metastases formation while being resistant to current cancer therapeutics. Cancer development and progression are demarcated by transcriptional dysregulation. In this article, we explore the epigenetic mechanisms shaping gene expression during tumorigenesis and cancer stem cell formation, with an emphasis on 3D chromatin architecture. Comparing the pluripotent stem cell state and epigenetic reprogramming to dedifferentiation in cellular transformation provides intriguing insight to chromatin dynamics. We suggest that the 3D chromatin architecture could be used as a target for re-sensitizing cancer stem cells to therapeutics.
引用
收藏
页码：440 / 454
页数：15
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