MicroRNAs in Cancer

被引：1857

作者：

Lee, Yong Sun ^{[1
]}

Dutta, Anindya ^{[1
]}

机构：

[1] Univ Virginia, Dept Biochem & Mol Genet, Charlottesville, VA 22908 USA

来源：

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE | 2009年 / 4卷

基金：

美国国家卫生研究院;

关键词：

tumorigenesis; oncogene; tumor suppressor; microRNA expression profile; diagnosis and prognosis; therapy; REAL-TIME PCR; TUMOR-SUPPRESSOR GENE; MESSENGER-RNA; POSTTRANSCRIPTIONAL REGULATION; CELL-PROLIFERATION; DOWN-REGULATION; EXPRESSION PROFILE; PROTEIN EXPRESSION; LUNG-CANCER; GENOMIC REGIONS;

D O I：

10.1146/annurev.pathol.4.110807.092222

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Within the past few years, studies on microRNA (miRNA) and cancer have burst onto the scene. Profiling of the miRNome (global miRNA expression levels) has become prevalent, and abundant miRNome data are currently available for various cancers. The pattern of miRNA expression can be correlated with cancer type, stage, and other clinical variables, so miRNA profiling can be used as a tool for cancer diagnosis and prognosis. miRNA expression analyses also suggest oncogenic (or tumor-suppressive) roles of miRNAs. miRNAs play roles in almost all aspects of cancer biology, such as proliferation, apoptosis, invasion/metastasis, and angiogenesis. Given that many miRNAs are deregulated in cancers but have not yet been further studied, it is expected that more miRNAs will emerge as players in the etiology and progression of cancer. Here we also discuss miRNAs as a tool for cancer therapy.

引用

页码：199 / 227

页数：29

共 210 条

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