Modulation of Short-Chain Fatty Acids as Potential Therapy Method for Type 2 Diabetes Mellitus

被引：56

作者：

Tang, Ruiqi ^{[1
]}

Li, Lanjuan ^{[1
]}

机构：

[1] Zhejiang Univ, Collaborat Innovat Ctr Diag & Treatment Infect Di, Natl Clin Res Ctr Infect Dis, Coll Med,Affiliated Hosp 1,State Key Lab Diag & T, Hangzhou 310003, Zhejiang, Peoples R China

来源：

CANADIAN JOURNAL OF INFECTIOUS DISEASES & MEDICAL MICROBIOLOGY | 2021年 / 2021卷

基金：

中国国家自然科学基金;

关键词：

GLUCAGON-LIKE PEPTIDE-1; SODIUM-BUTYRATE; GUT MICROBIOTA; BETA-CELL; INSULIN-SECRETION; BODY-WEIGHT; INTESTINAL MICROBIOTA; APPETITE REGULATION; ENERGY-METABOLISM; HDAC INHIBITOR;

D O I：

10.1155/2021/6632266

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

In recent years, the relationship between intestinal microbiota (IM) and the pathogenesis of type 2 diabetes mellitus (T2DM) has attracted much attention. The beneficial effects of IM on the metabolic phenotype of the host are often considered to be mediated by short-chain fatty acids (SCFAs), mainly acetate, butyrate, and propionate, the small-molecule metabolites derived from microbial fermentation of indigestible carbohydrates. SCFAs not only have an essential role in intestinal health but might also enter the systemic circulation as signaling molecules affecting the host's metabolism. In this review, we summarize the effects of SCFAs on glucose homeostasis and energy homeostasis and the mechanism through which SCFAs regulate the function of metabolically active organs (brain, liver, adipose tissue, skeletal muscle, and pancreas) and discuss the potential role of modulation of SCFAs as a therapeutic method for T2DM.

引用

页数：13

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