The minimum clinically important difference: which direction to take

被引：76

作者：

Draak, T. H. P. ^{[1
]}

de Greef, B. T. A. ^{[1
,2
]}

Faber, C. G. ^{[1
]}

Merkies, I. S. J. ^{[1
,3
]}

机构：

[1] Maastricht Univ, Dept Neurol, Med Ctr, Maastricht, Netherlands

[2] Maastricht Univ, Dept Clin Epidemiol & Med Technol Assessment, Med Ctr, Maastricht, Netherlands

[3] St Elizabeth Hosp, Dept Neurol, Willemstad, Curacao

来源：

EUROPEAN JOURNAL OF NEUROLOGY | 2019年 / 26卷 / 06期

基金：

欧盟地平线“2020”;

关键词：

minimum clinically important difference (MCID); QUALITY-OF-LIFE; STATISTICAL SIGNIFICANCE; INTRAVENOUS IMMUNOGLOBULIN; INTRAINDIVIDUAL CHANGES; PATIENT; RELEVANCE; TRIAL;

D O I：

10.1111/ene.13941

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Over the past decades in modern medicine, there has been a shift from statistical significance to clinical relevance when it comes to interpreting results from clinical trials. A concept that is increasingly being used as a surrogate for clinical relevance and effect size calculation is the minimum clinically important difference (MCID). In this paper, an overview is presented of the most important aspects of the MCID concept used in research trials and a discussion of what this means for the neurological patient in clinical trials and daily practice is given. Is the MCID the best outcome measure cut-off to be implemented?

引用

页码：850 / 855

页数：6

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