Spasmolytic activity of some plants used by the Otomi Indians of Queretaro (Mexico) for the treatment of gastrointestinal disorders

被引：37
|
作者：
Rojas, A [1 ]
Bah, M
Rojas, JI
Serrano, V
Pacheco, S
机构：
[1] Univ Autononma Queretaro, Fac Quim, Ctr Univ, Queretaro 76010, Mexico
[2] Univ Autononma Queretaro, Escuela Biol, Ctr Univ, Queretaro 76010, Mexico
来源：
PHYTOMEDICINE | 1999年 / 6卷 / 05期
关键词：
Baccharis heterophylla; Desmodium grahami; Dyssodia pinnata; Gentiana spathacea; Loeselia mexicana; Selaginella pallescens; Zornia diphylla; Datura lanosa; smooth muscle relaxation; spasmolytic effect; rat ileum; antimicrobial effect;
D O I：
10.1016/S0944-7113(99)80061-0
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The present study was performed to investigate the effect of chloroform-methanol (1:1) extracts derived from Baccharis heterophylla H. B. K (Asteraceae), Desmodium grahami Gray (Leguminosae), Dyssodia pinnata var. pinnata Rob. (Asteraceae), Gentiana spathacea H. B. K. (Gentianaceae), Loeselia mexicana Brand. (Polemoniaceae), Selaginella pallescens Spring. (Selaginellaceae) and Zornia diphylla Pers. (Fabaceae) on the spontaneous contractions of isolated rat ileum. The concentration-response curves and IC50 values were obtained and the respective relaxant potencies were compared with that of the CHCl3-MeOH (1:1) extract of Datura lanosa. The data showed that all the extracts produce a concentration-dependent inhibition of spontaneous ileum contractions. In addition, the antimicrobial activity of the extracts against pathogenic enterobacteria was tested. The pharmacological actions shown by the extracts of the selected species tend to support ethnomedical use of the plants for the treatment of gastrointestinal disorders.
引用
收藏
页码：367 / 371
页数：5
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