SYNTHESIS AND ANTIFUNGAL ACTIVITY OF 1-AMINOMETHYL-3-{4-(CHLOROBENZYLOXY) BENZOYLHYDRAZONO}-4, 5/5, 6-DICHLOROINDOLIN-2-ONES

3-{4-(Chlorobenzyloxy) benzoylhydrazono}-4,5/5,6-dichloroindolin-2-ones 1a,b-5a,b, were synthesized by the condensation of 4-(chlorobenzyloxy) benzoylhydrazines and 4,5/5, 6-dichloroindolin-2,3-diones. Compounds 1a,b-5a,b when subjected to Mannich reaction with secondary heterocyclic amines in the presence of formaldehyde, furnished 1-aminomethyl-3-{4-(chlorobenzyloxy) benzoylhydrazono}-4, 5/5, 6-dichloroindolin-2-ones 6a,b-20a,b. The structures of the compounds have been established by means of spectral (IR and H-1 NMR) and elemental analysis. The compounds have been screened for their antifungal potential against human pathogenic fungi.