Developing a core outcome set for hip fracture trials

被引:114
作者
Haywood, K. L. [1 ]
Griffin, X. L. [2 ]
Achten, J. [3 ]
Costa, M. L. [4 ]
机构
[1] Univ Warwick, Warwick Med Sch, Royal Coll Nursing Res Inst, Coventry CV4 7AL, W Midlands, England
[2] Univ Warwick, Warwick Med Sch, Coventry CV2 2DX, W Midlands, England
[3] Univ Warwick, Warwick Med Sch, Warwick Clin Trials Unit, Coventry CV2 2DX, W Midlands, England
[4] Univ Warwick, Warwick Med Sch, Warwick Clin Trials Unit, Coventry CV4 7AL, W Midlands, England
基金
美国国家卫生研究院;
关键词
QUALITY-OF-LIFE; OLDER-PEOPLE; RHEUMATOID-ARTHRITIS; PATIENT; HEALTH; CONSENSUS; FATIGUE; OMERACT; QUESTIONNAIRE; PERCEPTIONS;
D O I
10.1302/0301-620X.96B8.33766
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
The lack of a consensus for core health outcomes that should be reported in clinical research has hampered study design and evidence synthesis. We report a United Kingdom consensus for a core outcome set (COS) for clinical trials of patients with a hip fracture. We adopted a modified nominal group technique to derive consensus on 1) which outcome domains should be measured, and 2) methods of assessment. Participants reflected a diversity of perspectives and experience. They received an evidence synthesis and postal questionnaire in advance of the consensus meeting, and ranked the importance of candidate domains and the relevance and suitability of short-listed measures. During the meeting, pre-meeting source data and questionnaire responses were summarised, followed by facilitated discussion and a final plenary session. A COS was determined using a closed voting system: a 70% consensus was required. Consensus supported a five-domain COS: mortality, pain, activities of daily living, mobility, and health-related quality of life (HRQL). Single-item measures of mortality and mobility (indoor/outdoor walking status) and a generic multi-item measure of HRQL - the EuroQoL EQ-5D - were recommended. These measures should be included as a minimum in all hip fracture trials. Other outcome measures should be added depending on the particular interventions being studied.
引用
收藏
页码:1016 / 1023
页数:8
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