Natural and induced regulation of Th1/Th2 balance

被引:0
作者
Mitchison, NA
Schuhbauer, D
Müller, B
机构
[1] UCL, Windeyer Inst Med Sci, Dept Immunol, London W1P 6DB, England
[2] Deutsches Rheuma Forschungs Zentrum, Berlin, Germany
来源
SPRINGER SEMINARS IN IMMUNOPATHOLOGY | 1999年 / 21卷 / 03期
基金
英国惠康基金;
关键词
D O I
暂无
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Because Th1/Th2 balance is perturbed during immunological disease, the design of strategies aiming at its rectification has become a priority. The alteration of the balance in pregnancy so as to promote survival of the fetal allograft lends credibility to this aim. Attenuation of the activation signal delivered through the T cell receptor (TCR) represents a promising approach. It is supported by the high level of poly morphism in the MHC class IT promoter, which regulates the natural TCR signal and thus modulates Th1/Th2 differentiation. Further support comes from the Th2 shift that occurs in JNK knockout mice, and with kinase inhibitors and anti-CD4 monoclonal antibodies applied in vitro. The approach has implications for nasal tolerance and inhibition of IL-12 production. The further range of options for Th1/Th2 modulation, which are presented throughout this issue of the journal, are here summarised and evaluated.
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页码:199 / 210
页数:12
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