Prevalence of Food Sensitization and Food Allergy in Children Across Europe

被引：160

作者：

Lyons, Sarah A. ^{[1
]}

Clausen, Michael ^{[2
]}

Knulst, Andre C. ^{[1
]}

Ballmer-Weber, Barbara K. ^{[3
,4
,5
]}

Fernandez-Rivas, Montserrat ^{[6
]}

Barreales, Laura ^{[7
]}

Bieli, Christian ^{[8
]}

Dubakiene, Ruta ^{[9
]}

Fernandez-Perez, Cristina ^{[7
]}

Jedrzejczak-Czechowicz, Monika ^{[10
]}

Kowalski, Marek L. ^{[10
]}

Kralimarkova, Tanya ^{[11
]}

Kummeling, Ischa ^{[12
]}

Mustakov, Tihomir B. ^{[11
]}

Papadopoulos, Nikolaos G. ^{[13
,14
]}

Popov, Todor A. ^{[15
]}

Xepapadaki, Paraskevi ^{[13
]}

Welsing, Paco M. J. ^{[16
]}

Potts, James ^{[12
]}

Mills, E. N. Clare ^{[17
,18
]}

van Ree, Ronald ^{[19
,20
]}

Burney, Peter G. J. ^{[12
]}

Thuy-My Le ^{[1
]}

机构：

[1] Univ Utrecht, Univ Med Ctr Utrecht, Dept Dermatol & Allergol, Utrecht, Netherlands

[2] Landspitali Univ Hosp, Childrens Hosp, Reykjavik, Iceland

[3] Univ Hosp Zurich, Dept Dermatol, Allergy Unit, Zurich, Switzerland

[4] Univ Zurich, Fac Med, Zurich, Switzerland

[5] Kantonsspital St Gallen, Clin Dermatol & Allergol, St Gallen, Switzerland

[6] ARADyAL, IdISSC, Hosp Clin San Carlos, Allergy Dept, Madrid, Spain

[7] UCM, Hosp Clin San Carlos, IdISSC, Serv Med Prevent,Epidemiol Unit, Madrid, Spain

[8] Univ Childrens Hosp, Dept Paediat Pulmonol, Zurich, Switzerland

[9] Vilnius Univ, Med Fac, Vilnius, Lithuania

[10] Med Univ Lodz, Dept Allergy & Immunol, Lodz, Poland

[11] Med Univ Sofia, Alexandrovska Hosp, Clin Ctr Allergol, Sofia, Bulgaria

[12] Imperial Coll London, Natl Heart & Lung Inst, London, England

[13] Univ Athens, Pediat Clin 2, Allergy Dept, Athens, Greece

[14] Univ Manchester, Lydia Becker Inst Immunol & Inflammat, Div Infect Immun & Resp Med, Manchester, Lancs, England

[15] Univ Hosp Sv Ivan Rilski, Sofia, Bulgaria

[16] Univ Med Ctr Utrecht, Div Internal Med & Dermatol, Utrecht, Netherlands

[17] Univ Manchester, Manchester Inst Biotechnol, Div Infect Immun & Resp Med, Manchester, Lancs, England

[18] Univ Manchester, Lydia Becker Inst Immunol & Inflammat, Manchester, Lancs, England

[19] Univ Amsterdam, Med Ctr, AMC, Dept Expt Immunol, Amsterdam, Netherlands

[20] Univ Amsterdam, Med Ctr, AMC, Dept Otorhinolaryngol, Amsterdam, Netherlands

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE | 2020年 / 8卷 / 08期

基金：

英国生物技术与生命科学研究理事会;

关键词：

Food allergy; Food sensitization; Prevalence; Causative foods; Cross-reactivity; Europe; Children; IGE; HYPERSENSITIVITY; EPIDEMIOLOGY; RELEVANT; SYMPTOMS;

D O I：

10.1016/j.jaip.2020.04.020

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

BACKGROUND: For adults, prevalence estimates of food sensitization (FS) and food allergy (FA) have been obtained in a standardized manner across Europe. For children, such estimates are lacking. OBJECTIVES: To determine the prevalence of self-reported FA, FS, probable FA (symptoms plus IgE sensitization), and challenge-confirmed FA in European school-age children. METHODS: Data on self-reported FA were collected through a screening questionnaire sent to a random sample of the general population of 7- to 10-year-old children in 8 European centers in phase I of the EuroPrevall study. Data on FS and probable FA were obtained in phase II, comprising an extensive questionnaire on reactions to 24 commonly implicated foods, and serology testing. Food challenge was performed in phase III. RESULTS: Prevalence (95% CI) of self-reported FA ranged from 6.5% (5.4-7.6) in Athens to 24.6% (22.8-26.5) in Lodz; prevalence of FS ranged from 11.0% (9.7-12.3) in Reykjavik to 28.7% (26.9-30.6) in Zurich; and prevalence of probable FA ranged from 1.9% (0.8-3.5) in Reykjavik to 5.6% (3.6-8.1) in Lodz. In all centers, most food-sensitized subjects had primary (nonecross-reactive) FS. However, FS due to birch pollen related cross-reactivity was also common in Central-Northern Europe. Probable FA to milk and egg occurred frequently throughout Europe; to fish and shrimp mainly in the Mediterranean and Reykjavik. Peach, kiwi, and peanut were prominent sources of plant FA in most countries, along with notably hazelnut, apple, carrot, and celery in Central-Northern Europe and lentils and walnut in the Mediterranean. CONCLUSIONS: There are large geograhical differences in the prevalence of FS and FA in school-age children across Europe. Both primary and cross-reactive FS and FA occur frequently. (C) 2020 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology

引用

页码：2736 / +

页数：20

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