Recent Progress in the Synthesis of Bifunctional Diethylenetriaminepentaacetic Acid Derivatives Ligand for Magnetic Resonance Imaging Contrast Agent

被引：5

作者：

Wan, Fuxian ^{[1
]}

Yu, Kaichao ^{[2
]}

机构：

[1] Shan Dong Agr Univ, Coll Chem & Mat Sci, Tai An 271018, Shandong, Peoples R China

[2] Huazhong Univ Sci & Technol, Sch Chem & Chem Engn, Wuhan 430074, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 34卷 / 04期

基金：

中国国家自然科学基金;

关键词：

magnetic resonance imaging; DTPA; gadolinium-complexes; bifunctional chelator; synthesis; CHAIN ALKYL ESTERS; IN-VIVO; L-LYSINE; PHYSICOCHEMICAL CHARACTERIZATION; RELAXATION ENHANCEMENT; GADOLINIUM COMPLEXES; LANTHANIDE COMPLEXES; GD(III) COMPLEXES; DTPA DERIVATIVES; BUILDING-BLOCKS;

D O I：

10.6023/cjoc201310052

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Diethylenetriaminepentaacetic acid (DTPA) and its derivatives have been used in chemistry, biology, medicine and many other fields due to their coordination properties, especially, used as magnetic resonance imaging (MRI) contrast agent. Bifunctional-DTPA ligand can be easily and readily linked to various biomolecules. It is of primary importance for the development high relaxation efficiency and/or targeted MRI contrast agents, but the synthesis of bifunctional-DTPA ligand is rather difficult. In this review, various synthetic methods for synthesizing these compounds are summarized.

引用

页码：613 / 629

页数：17

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