Brain atrophy after immunoablation and stem cell transplantation in multiple sclerosis

被引：72
作者：
Chen, J. T.
Collins, D. L.
Atkins, H. L.
Freedman, M. S.
Galal, A.
Arnold, D. L.
机构：
[1] Montreal Neurol Hosp & Inst, McConnell Brain Imaing Ctr, Montreal, PQ, Canada
[2] Ottawa Hosp, Ottawa, ON, Canada
[3] McGill Univ, Ctr Hlth, Stem Cell Transplant Program, Montreal, PQ, Canada
来源：
NEUROLOGY | 2006年 / 66卷 / 12期
关键词：
D O I：
10.1212/01.wnl.0000219816.44094.f8
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The authors measured brain atrophy in nine patients undergoing immunoablation and autologous hematopoietic stem cell transplantation for multiple sclerosis. From baseline to 1 month after treatment, atrophy was 10 times faster than before treatment. A patient with non-CNS lymphoma showed comparable acute brain atrophy after analogous therapy. These observations suggest that brain atrophy after immunoablation may not be due entirely to the resolution of edema but may be related to chemotoxicity.
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页码：1935 / 1937
页数：3
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