The clinical and diagnostic role of microRNAs in ovarian carcinoma

被引：50
作者：
Davidson, Ben [1 ,2 ]
Trope, Claes G. [2 ,3 ]
Reich, Reuven [4 ]
机构：
[1] Norwegian Radium Hosp, Oslo Univ Hosp, Dept Pathol, N-0310 Oslo, Norway
[2] Univ Oslo, Inst Clin Med, Fac Med, N-0310 Oslo, Norway
[3] Norwegian Radium Hosp, Oslo Univ Hosp, Dept Gynecol Oncol, N-0310 Oslo, Norway
[4] Hebrew Univ Jerusalem, Inst Drug Res, Sch Pharm, Fac Med, IL-91120 Jerusalem, Israel
来源：
GYNECOLOGIC ONCOLOGY | 2014年 / 133卷 / 03期
关键词：
MicroRNA; Ovarian carcinoma; Diagnosis; Chemotherapy; Prognosis; DOWN-REGULATION; MULTIDRUG-RESISTANCE; TUMOR PROGRESSION; POOR-PROGNOSIS; FREE SURVIVAL; CANCER CELLS; EXPRESSION; CISPLATIN; TUMORIGENESIS; SENSITIVITY;
D O I：
10.1016/j.ygyno.2014.03.575
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Objective. MicroRNAs (miRNAs, miRs) are non-coding RNAs which post-transcriptionally regulate miNA synthesis. Data regarding the expression and clinical relevance of miRNAs and the miRNA-regulating machinery in ovarian carcinoma has been rapidly expanding in recent years. This review presents current knowledge in this area. Methods. PubMed search was undertaken using the terms 'ovarian' and 'microRNA'. Results. A total of 492 papers were identified, of which approximately 100 were publications in English focusing exclusively or partly on clinical ovarian carcinoma specimens. These studies have identified multiple miRNAs with a potential role in the diagnosis, biology and progression of ovarian carcinoma, as well as on predicting chemoresponse and determining prognosis. Conclusions. The presented data support a clinical role for miRNAs in ovarian carcinoma and suggest that miRNA-regulated pathways may be of relevance for novel therapeutics. Novel technologies offer new possibilities for wide-scale miRNA-based classification of OC. Further genomic research focusing on larger series of tumors of similar histological type in combination with experimental approaches is likely to expand our understanding of the role of miRNAs in this cancer. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码：640 / 646
页数：7
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