VARIABILITY AND DISTRIBUTION OF MUSCLE STRENGTH AND ITS DETERMINANTS IN HUMANS

被引:9
作者
Stebbings, Georgina K. [1 ]
Morse, Christopher I. [1 ]
Williams, Alun G. [1 ]
Day, Stephen H. [1 ]
机构
[1] Manchester Metropolitan Univ, Inst Performance Res, Ctr Genom Res Exercise Performance & Hlth, Crewe CW1 5DU, Cheshire, England
关键词
passive force; rat extensor digitorum longus muscle; muscle force length; spread of BTX-A; range of force exertion; bi-articular muscle; botulinum toxin type A; MOMENT ARM LENGTH; VIVO SPECIFIC TENSION; CROSS-SECTIONAL AREA; SKELETAL-MUSCLE; IN-VIVO; PATELLAR TENDON; FIBER-TYPE; KNEE EXTENSION; FORCE; YOUNG;
D O I
10.1002/mus.24075
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Introduction: The goal of this study was to test the hypothesis that botulinum toxin type A (BTX-A) injection in rat tibialis anterior (TA) muscle affects the mechanics of its bi-articular synergist, both actively and passively. Methods: Two groups of Wistar rats were tested: control (no BTX-A) and BTX (0.1 U of BTX-A) animals were injected exclusively to the mid-belly of TA. Extensor digitorum longus (EDL) muscle isometric forces were measured after proximal and distal lengthening. Results: Five days after injection, BTX-A administration changed EDL mechanics: (1) active forces decreased (proximal muscle length dependently); (2) length range of active force exertion decreased both proximally and distally; and (3) passive muscle forces increased. Conclusions: Effects of BTX-A appear to not be limited to decreased active muscle tone, but may cause also a narrower active range of movement and increased passive resistance. Through spread of BTX-A to a bi-articular muscle, such effects are plausible for both joints spanned. Muscle Nerve 49: 866-878, 2014
引用
收藏
页码:879 / 886
页数:8
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