Toxicity of engineered metal oxide nanomaterials mediated by nano-bio-eco-interactions: a review and perspective

被引:90
作者
He, Xiaojia [1 ]
Aker, Winfred G. [1 ]
Fu, Peter P. [2 ]
Hwang, Huey-Min [1 ]
机构
[1] Jackson State Univ, Jackson, MS 39217 USA
[2] Natl Ctr Toxicol Res, Jefferson, AR USA
基金
美国国家科学基金会;
关键词
TITANIUM-DIOXIDE NANOPARTICLES; TIO2; NANOPARTICLES; ZINC-OXIDE; ZNO NANOPARTICLES; ESCHERICHIA-COLI; PROTEIN CORONA; BIOPHYSICOCHEMICAL INTERACTIONS; INORGANIC NANOPARTICLES; SURFACE-ADSORPTION; OPTIMAL DESCRIPTOR;
D O I
10.1039/c5en00094g
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Along with the expanding use of engineered metal oxide nanomaterials (MONMs), there is a growing concern over their unintentional adverse toxicological effects on human health and the environment upon release and exposure. It is inevitable that biota will be exposed to nanomaterials, through intentional administration or inadvertent contact under such circumstances. Therefore, a thorough investigation of the potential nanotoxicity of MONMs at the nano-bio-eco interface is urgently needed. In general, nanomaterials interact with their surrounding environments, biotic and abiotic, immediately upon introduction into the environment. The behavior and fate of MONMs are influenced by the dynamics of the environment. Thus, understanding the interactions at the nano-bio-eco interface is necessary for selecting and designing MONMs with minimum adverse impacts. Despite the limitations of currently available techniques, careful characterization of nanomaterials and the choosing of methodologies that promote further risk assessment promise more reliable and accurate data output. Conventional toxicological analysis techniques lack the power to handle the large datasets generated from in vitro/in vivo observations. This paper provides a comprehensive review of the recent experimental and theoretical studies on the toxicity of MONMs mediated by two-way or three-way interactions. In the Perspectives, we also call for more open collaborations between industry, academia, and research labs to facilitate nano-toxicological studies focused specifically on interactions at the nano-bio-eco interface, leading to safe and effective nanotechnology for commercial, environmental, and medicinal use.
引用
收藏
页码:564 / 582
页数:19
相关论文
共 149 条
[51]   Using a holistic approach to assess the impact of engineered nanomaterials inducing toxicity in aquatic systems [J].
He, Xiaojia ;
Aker, Winfred G. ;
Leszczynski, Jerzy ;
Hwang, Huey-Min .
JOURNAL OF FOOD AND DRUG ANALYSIS, 2014, 22 (01) :128-146
[52]   In vitro evaluation of cytotoxicity of engineered metal oxide nanoparticles [J].
Hu, Xiaoke ;
Cook, Sean ;
Wang, Peng ;
Hwang, Huey-min .
SCIENCE OF THE TOTAL ENVIRONMENT, 2009, 407 (08) :3070-3072
[53]   Compare Analysis for the Nanotoxicity Effects of Different Amounts of Endocytic Iron Oxide Nanoparticles at Single Cell Level [J].
Huang, Chen-Yu ;
Ger, Tzong-Rong ;
Wei, Zung-Hang ;
Lai, Mei-Feng .
PLOS ONE, 2014, 9 (05)
[54]   Pulmonary instillation of low doses of titanium dioxide nanoparticles in mice leads to particle retention and gene expression changes in the absence of inflammation [J].
Husain, Mainul ;
Saber, Anne T. ;
Guo, Charles ;
Jacobsen, Nicklas R. ;
Jensen, Keld A. ;
Yauk, Carole L. ;
Williams, Andrew ;
Vogel, Ulla ;
Wallin, Hakan ;
Halappanavar, Sabina .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2013, 269 (03) :250-262
[55]  
Hwang HM, 2012, SUSTAINABLE PREPARAT
[56]   Electron Injection from Colloidal PbS Quantum Dots into Titanium Dioxide Nanoparticles [J].
Hyun, Byung-Ryool ;
Zhong, Yu-Wu. ;
Bartnik, Adam C. ;
Sun, Liangfeng ;
Abruna, Hector D. ;
Wise, Frank W. ;
Goodreau, Jason D. ;
Matthews, James R. ;
Leslie, Thomas M. ;
Borrelli, Nicholas F. .
ACS NANO, 2008, 2 (11) :2206-2212
[57]  
International Organization for Standardization, 2012, ISO/TS 12901-1:2012
[58]   Periodic table-based descriptors to encode cytotoxicity profile of metal oxide nanoparticles: A mechanistic QSTR approach [J].
Kar, Supratik ;
Gajewicz, Agnieszka ;
Puzyn, Tomasz ;
Roy, Kunal ;
Leszczynski, Jerzy .
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2014, 107 :162-169
[59]   Stability and Aggregation of Metal Oxide Nanoparticles in Natural Aqueous Matrices [J].
Keller, Arturo A. ;
Wang, Hongtao ;
Zhou, Dongxu ;
Lenihan, Hunter S. ;
Cherr, Gary ;
Cardinale, Bradley J. ;
Miller, Robert ;
Ji, Zhaoxia .
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2010, 44 (06) :1962-1967
[60]   Evidence for the mechanism of photocatalytic degradation of the bacterial wall membrane at the TiO2 interface by ATR-FTIR and laser kinetic spectroscopy [J].
Kiwi, J ;
Nadtochenko, V .
LANGMUIR, 2005, 21 (10) :4631-4641