Modes of regulation of ubiquitin-mediated protein degradation

被引：2
|
作者：
Kornitzer, D
Ciechanover, A
机构：
[1] Technion Israel Inst Technol, Bruce Rappaport Fac Med, Dept Mol Microbiol, IL-31096 Haifa, Israel
[2] Technion Israel Inst Technol, Bruce Rappaport Fac Med, Rappaport Family Inst Res Med Sci, Dept Biochem, Haifa, Israel
来源：
JOURNAL OF CELLULAR PHYSIOLOGY | 2000年 / 182卷 / 01期
关键词：
D O I：
10.1002/(SICI)1097-4652(200001)182:1<1::AID-JCP1>3.0.CO;2-V
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The ubiquitin-proteasome pathway is responsible for the major portion of specific cellular protein degradation. Ubiquitin-mediated degradation is involved in physiological regulation of many cellular processes, including cell cycle progression, differentiation, and signal transduction. Here, we review the basic mechanisms of the ubiquitin system and the various ways in which ubiquitin-mediated degradation can be modulated by physiological signals. J. Cell. Physiol. 182:1-11, 2000. (C) 2000 Wiley-Liss, Inc.
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页码：1 / 11
页数：11
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