Doxorubicin-loaded magnetic nanocapsules based on N-palmitoyl chitosan and magnetite: Synthesis and characterization

被引：35

作者：

Balan, Vera ^{[1
]}

Dodi, Gianina ^{[2
,3
]}

Tudorachi, Nita ^{[4
]}

Ponta, Oana ^{[5
,6
]}

Simon, Viorica ^{[5
,6
]}

Butnaru, Maria ^{[1
]}

Verestiuc, Liliana ^{[1
]}

机构：

[1] Gr T Popa Univ Med & Pharm, Fac Med Bioengn, 9-13 Kogalniceanu St, Iasi 700454, Romania

[2] Gheorghe Asachi Tech Univ Iasi, Fac Chem Engn & Environm Protect, Iasi 700050, Romania

[3] SCIENT Res Ctr Instrumental Anal, Bucharest 060114 6, Romania

[4] Petru Poni Inst Macromol Chem, Iasi 700487, Romania

[5] Univ Babes Bolyai, Fac Phys, Cluj Napoca 400084, Romania

[6] Univ Babes Bolyai, Inst Interdisciplinary Res Bionanosci, Cluj Napoca 400084, Romania

来源：

CHEMICAL ENGINEERING JOURNAL | 2015年 / 279卷

关键词：

Magnetic nanocapsules; N-palmitoyl chitosan; Doxorubicin; Double emulsion; DRUG-DELIVERY; ACYLATED CHITOSAN; CONTROLLED-RELEASE; MOLECULAR-WEIGHT; CANCER-THERAPY; NANOPARTICLES; MICELLES; MICROPARTICLES; ACETYLATION; MATRICES;

D O I：

10.1016/j.cej.2015.04.152

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Doxorubicin-loaded magnetic nanocapsules, based on N-palmitoyl chitosan and magnetite, have been prepared using a double emulsion method. The morphology and size of the nanocapsules have been investigated by transmission and scanning electron microscopy. Magnetic nanocapsules were nearly spherical in shape, with a mean diameter in the nanometer range, and positive zeta potential. Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD) and Energy Dispersive X-ray analysis (EDX) confirmed the structure of composite magnetic nanocapsules. Magnetic nanocapsules exhibited suitable magnetic saturation, superparamagnetic behavior and good ability to incorporate a chemotherapeutic agent, properties which can be exploited in many different areas of biomedicine. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：188 / 197

页数：10

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