Consumption of Dairy Products and Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

被引：68

作者：

Murphy, Neil ^{[1
]}

Norat, Teresa ^{[1
]}

Ferrari, Pietro ^{[2
]}

Jenab, Mazda ^{[2
]}

Bueno-de-Mesquita, Bas ^{[3
,4
]}

Skeie, Guri ^{[5
]}

Olsen, Anja ^{[6
]}

Tjonneland, Anne ^{[6
]}

Dahm, Christina C. ^{[7
,8
]}

Overvad, Kim ^{[8
]}

Boutron-Ruault, Marie Christine ^{[9
,10
]}

Clavel-Chapelon, Francoise ^{[9
,10
]}

Nailler, Laura ^{[9
,10
]}

Kaaks, Rudolf ^{[11
]}

Teucher, Birgit ^{[11
]}

Boeing, Heiner ^{[12
]}

Bergmann, Manuela M. ^{[12
]}

Trichopoulou, Antonia ^{[13
,14
]}

Lagiou, Pagona ^{[13
,15
,16
]}

Trichopoulos, Dimitrios ^{[14
,15
,16
]}

Palli, Domenico ^{[17
]}

Pala, Valeria ^{[18
]}

Tumino, Rosario ^{[19
,20
]}

Vineis, Paolo ^{[1
,21
]}

Panico, Salvatore ^{[22
]}

Peeters, Petra H. M. ^{[23
]}

Dik, Vincent K. ^{[4
]}

Weiderpass, Elisabete ^{[5
]}

Lund, Eiliv ^{[5
]}

Quiros Garcia, Jose Ramon ^{[24
]}

Zamora-Ros, Raul ^{[25
]}

Sanchez Perez, Maria Jose ^{[26
,27
]}

Dorronsoro, Miren ^{[28
]}

Navarro, Carmen ^{[27
,29
,30
]}

Ardanaz, Eva ^{[27
,31
]}

Manjer, Jonas ^{[32
]}

Almquist, Martin ^{[33
]}

Johansson, Ingegerd ^{[34
]}

Palmqvist, Richard ^{[35
]}

Khaw, Kay-Tee ^{[36
]}

Wareham, Nick ^{[37
]}

Key, Timothy J. ^{[38
]}

Crowe, Francesca L. ^{[38
]}

Fedirko, Veronika ^{[2
]}

Gunter, Marc J. ^{[1
]}

Riboli, Elio ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

[2] Int Agcy Res Canc, F-69372 Lyon, France

[3] Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands

[4] Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[5] Univ Tromso, Inst Community Med, Tromso, Norway

[6] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark

[7] Aarhus Univ Hosp, Dept Cardiol, Aalborg, Denmark

[8] Aarhus Univ, Sch Publ Hlth, Dept Epidemiol, Aarhus, Denmark

[9] Inst Gustave Roussy, INSERM, Ctr Res Epidemiol & Populat Hlth, F-94805 Villejuif, France

[10] Paris South Univ, UMRS 1018, F-94805 Villejuif, France

[11] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[12] German Inst Human Nutr, Dept Epidemiol, Potsdam, Germany

[13] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, Collaborating Ctr Food & Nutr Policies,WHO, GR-11527 Athens, Greece

[14] Hellen Hlth Fdn, Athens, Greece

[15] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[16] Acad Athens, Bur Epidemiol Res, Athens, Greece

[17] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy

[18] Fdn IRCCS Ist Nazl Tumori, Nutr Epidemiol Unit, Milan, Italy

[19] Civile MP Arezzo, Canc Registry, Asp Ragusa, Italy

[20] Civile MP Arezzo, Histopathol Unit, Asp Ragusa, Italy

[21] HuGeF Fdn, Turin, Italy

[22] Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy

[23] Univ Med Ctr Utrecht, Julius Ctr, Utrecht, Netherlands

[24] Publ Hlth Directorate, Asturias, Spain

[25] Environm & Canc Catalan Inst Oncol, Unit Nutr, Barcelona, Spain

[26] Andalusian Sch Publ Hlth, Granada, Spain

[27] CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain

[28] Basque Reg Hlth Dept & Ciberesp Biodonostia, Publ Hlth Div Gipuzkoa, San Sebastian, Spain

[29] Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain

[30] Univ Murcia, Sociosanitary Sci Dept, Murcia, Spain

[31] Navarre Publ Hlth Inst, Pamplona, Spain

[32] Lund Univ, Dept Plast Surg, Malmo, Sweden

[33] Lund Univ, Dept Surg, Malmo, Sweden

[34] Umea Univ, Dept Odontol, Umea, Sweden

[35] Umea Univ, Dept Med Biosci, Umea, Sweden

[36] Univ Cambridge, Cambridge, England

[37] MRC Epidemiol Unit, Cambridge, England

[38] Univ Oxford, Nuffield Dept Clin Med, Canc Epidemiol Unit, Oxford, England

来源：

PLOS ONE | 2013年 / 8卷 / 09期

基金：

英国医学研究理事会; 英国惠康基金; 欧洲研究理事会;

关键词：

DIETARY CALCIUM; VITAMIN-D; MILK-PRODUCTS; COLON-CANCER; RISK; COHORT; FOODS; FAT; METAANALYSIS; CALIBRATION;

D O I：

10.1371/journal.pone.0072715

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background: Prospective studies have consistently reported lower colorectal cancer risks associated with higher intakes of total dairy products, total milk and dietary calcium. However, less is known about whether the inverse associations vary for individual dairy products with differing fat contents. Materials and Methods: In the European Prospective Investigation into Cancer and Nutrition (EPIC), we investigated the associations between intakes of total milk and milk subtypes (whole-fat, semi-skimmed and skimmed), yoghurt, cheese, and dietary calcium with colorectal cancer risk amongst 477,122 men and women. Dietary questionnaires were administered at baseline. Multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models, adjusted for relevant confounding variables. Results: During the mean 11 years of follow-up, 4,513 incident cases of colorectal cancer occurred. After multivariable adjustments, total milk consumption was inversely associated with colorectal cancer risk (HR per 200 g/day 0.93, 95% CI: 0.89-0.98). Similar inverse associations were observed for whole-fat (HR per 200 g/day 0.90, 95% CI: 0.82-0.99) and skimmed milk (HR per 200 g/day 0.90, 95% CI: 0.79-1.02) in the multivariable models. Inverse associations were observed for cheese and yoghurt in the categorical models; although in the linear models, these associations were non-significant. Dietary calcium was inversely associated with colorectal cancer risk (HR per 200 mg/day 0.95, 95% CI: 0.91-0.99); this association was limited to dairy sources of calcium only (HR per 200 mg/day 0.95, 95% CI: 0.91-0.99), with no association observed for non-dairy calcium sources (HR per 200 mg/day 1.00, 95% CI: 0.81-1.24). Conclusions: Our results strengthen the evidence for a possible protective role of dairy products on colorectal cancer risk. The inverse associations we observed did not differ by the fat content of the dairy products considered.

引用

页数：12

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