Ivermectin as a Broad-Spectrum Host-Directed Antiviral: The Real Deal?

被引：52

作者：

Jans, David A. ^{[1
]}

Wagstaff, Kylie M. ^{[2
]}

机构：

[1] Monash Univ, Biomed Discovery Inst, Dept Biochem & Mol Biol, Nucl Signaling Lab, Monash, Vic 3800, Australia

[2] Monash Univ, Biomed Discovery Inst, Dept Biochem & Mol Biol, Canc Targeting & Nucl Therapeut Lab, Monash, Vic 3800, Australia

来源：

CELLS | 2020年 / 9卷 / 09期

基金：

英国医学研究理事会;

关键词：

ivermectin; antiviral; SARS-CoV-2; COVID-19; flavivirus; dengue virus; Zika virus; NUCLEAR-LOCALIZATION; CAPSID PROTEIN; INHIBITOR; IMPORT; PHARMACOKINETICS; REPLICATION; PROTECTION; GOSSYPOL; SAFETY;

D O I：

10.3390/cells9092100

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The small molecule macrocyclic lactone ivermectin, approved by the US Food and Drug Administration for parasitic infections, has received renewed attention in the last eight years due to its apparent exciting potential as an antiviral. It was identified in a high-throughput chemical screen as inhibiting recognition of the nuclear localizing Human Immunodeficiency Virus-1 (HIV-1) integrase protein by the host heterodimeric importin (IMP) alpha/beta 1 complex, and has since been shown to bind directly to IMP alpha to induce conformational changes that prevent its normal function in mediating nuclear import of key viral and host proteins. Excitingly, cell culture experiments show robust antiviral action towards HIV-1, dengue virus (DENV), Zika virus, West Nile virus, Venezuelan equine encephalitis virus, Chikungunya virus, Pseudorabies virus, adenovirus, and SARS-CoV-2 (COVID-19). Phase III human clinical trials have been completed for DENV, with >50 trials currently in progress worldwide for SARS-CoV-2. This mini-review discusses the case for ivermectin as a host-directed broad-spectrum antiviral agent for a range of viruses, including SARS-CoV-2.

引用

页码：1 / 19

页数：19

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