Mammalian sirtuins - emerging roles in physiology, aging, and calorie restriction

被引：1091
作者：
Haigis, Marcia C. [1 ]
Guarente, Leonard P. [1 ]
机构：
[1] MIT, Dept Biol, Cambridge, MA 02139 USA
来源：
GENES & DEVELOPMENT | 2006年 / 20卷 / 21期
关键词：
Sir2; aging; glutamate dehydrogenase; SIRT1-7; mitochondria; insulin; calorie restriction;
D O I：
10.1101/gad.1467506
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Sir2 is an NAD-dependent deacetylase that connects metabolism with longevity in yeast, worms and flies. Mammals contain seven homologs of yeast Sir2, SIRT1-7. Here, we review recent findings demonstrating the role of these mammalian sirtuins as regulators of physiology, calorie restriction, and aging. The current findings sharpen our understanding of sirtuins as potential pharmacological targets to treat the major diseases of aging.
引用
收藏
页码：2913 / 2921
页数：9
相关论文
共 90 条
[1]   FoxOs at the crossroads of cellular metabolism, differentiation, and transformation [J].
Accili, D ;
Arden, KC .
CELL, 2004, 117 (04) :421-426
[2]   Yeast life-span extension by calorie restriction is independent of NAD fluctuation [J].
Anderson, RM ;
Latorre-Esteves, M ;
Neves, AR ;
Lavu, S ;
Medvedik, O ;
Taylor, C ;
Howitz, KT ;
Santos, H ;
Sinclair, DA .
SCIENCE, 2003, 302 (5653) :2124-2126
[3]   Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae [J].
Anderson, RM ;
Bitterman, KJ ;
Wood, JG ;
Medvedik, O ;
Sinclair, DA .
NATURE, 2003, 423 (6936) :181-185
[4]   Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration [J].
Araki, T ;
Sasaki, Y ;
Milbrandt, J .
SCIENCE, 2004, 305 (5686) :1010-1013
[5]   LIFE EXTENSION BY DIETARY RESTRICTION IN THE BOWL AND DOILY SPIDER, FRONTINELLA-PYRAMITELA [J].
AUSTAD, SN .
EXPERIMENTAL GERONTOLOGY, 1989, 24 (01) :83-92
[6]   Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat [J].
Barzilai, N ;
Banerjee, S ;
Hawkins, M ;
Chen, W ;
Rossetti, L .
JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (07) :1353-1361
[7]   A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages [J].
Bellizzi, D ;
Rose, G ;
Cavalcante, P ;
Covello, G ;
Dato, S ;
De Rango, F ;
Greco, V ;
Maggiolini, M ;
Feraco, E ;
Mari, V ;
Franceschi, C ;
Passarino, G ;
De Benedictis, G .
GENOMICS, 2005, 85 (02) :258-263
[8]   C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span [J].
Berdichevsky, Ala ;
Viswanathan, Mohan ;
Horvitz, H. Robert ;
Guarente, Leonard .
CELL, 2006, 125 (06) :1165-1177
[9]   The Sir2 family of protein deacetylases [J].
Blander, G ;
Guarente, L .
ANNUAL REVIEW OF BIOCHEMISTRY, 2004, 73 :417-435
[10]   Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic β cells [J].
Bordone, L ;
Motta, MC ;
Picard, F ;
Robinson, A ;
Jhala, US ;
Apfeld, J ;
McDonagh, T ;
Lemieux, M ;
McBurney, M ;
Szilvasi, A ;
Easlon, EJ ;
Lin, SJ ;
Guarente, L .
PLOS BIOLOGY, 2006, 4 (02) :210-220
123456789