The decision of Great Britain to exit the European Union has taken everyone by surprise. Financial markets, which were optimistic before the vote, reacted immediately to this decision calling for prompt intervention by policy authorities. It's obvious that this decision has to be observed and implemented in the best possible way by all responsible bodies, both in EU and in the Great Britain, however it's of upmost importance to estimate the medium to long term implications in all its economic, political and social aspects. The purpose of this article is to briefly outline some of the reasons and the possible negative effects of BREXIT, from an economic point of view, and to outline some short considerations on the future of the European Union.