Prenatal Stem Cell Transplantation and Gene Therapy

被引：16

作者：

Santore, Matthew T. ^{[1
]}

Roybal, Jessica L. ^{[1
]}

Flake, Alan W. ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Dept Surg, Childrens Hosp Philadelphia,Childrens Ctr Fetal R, Philadelphia, PA 19104 USA

来源：

CLINICS IN PERINATOLOGY | 2009年 / 36卷 / 02期

关键词：

Prenatal treatment; Fetal therapy; Gene therapy; Hematopoietic stem cell transplantation; Immunologic tolerance; IN-UTERO TRANSPLANTATION; BONE-MARROW-TRANSPLANTATION; SEVERE COMBINED IMMUNODEFICIENCY; VERSUS-HOST-DISEASE; GESTATIONAL INTRAAMNIOTIC INJECTION; LEVEL ALLOGENEIC CHIMERISM; TERM TRANSGENE EXPRESSION; CYSTIC-FIBROSIS PHENOTYPE; FETAL LIVER; LONG-TERM;

D O I：

10.1016/j.clp.2009.03.006

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

At the present time, the most likely and eminent application of stem cell therapy to the fetus is in utero hematopoietic stem cell transplantation (IUHCT), and this stem cell type will be discussed as a paradigm for all prenatal stem cell therapy. The authors feel that the most likely initial application of IUHCT will use adult HSC derived from bone marrow (BM) or peripheral blood (PB), and will focus this article on this specific approach. The article also reviews the experimental data that support the capacity of IUHCT to induce donor-specific tolerance.

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页码：451 / +

页数：22

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