Amino acid acquisition, cross-pathway control, and virulence in Aspergillus

被引：11

作者：

Braus, Gerhard H. ^{[1
]}

Sasse, Christoph ^{[1
]}

Krappmann, Sven ^{[1
]}

机构：

[1] Univ Gottingen, Inst Microbiol & Genet, Dept Microbiol & Mol Genet, D-37077 Gottingen, Germany

来源：

MEDICAL MYCOLOGY | 2006年 / 44卷

关键词：

amino acid supply; cross-pathway control; CpcA/Gcn4p;

D O I：

10.1080/13693780600898029

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Supply of all amino acids required for translation is crucial for the synthesis of new proteins. Fungal amino acid biosynthesis has to be coordinated with amino acid uptake as well as protein degradation. A global regulator that connects amino acid biosynthesis and developmental programs is the transcription factor CpcA/Gcn4p. This transcriptional activator is conserved within the fungal kingdom and the cellular levels of this protein are carefully regulated. Deletion of the encoding cpcA gene in the opportunistic pathogen Aspergillus fumigatus results in impaired virulence in immuno-compromised mice, suggesting a role of the cross-pathway control system in fungal pathogenicity.

引用

页码：S91 / S94

页数：4

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