Genotyping in Sickle Cell Disease Patients: The French Strategy

被引：21

作者：

Floch, Aline ^{[1
,2
,3
,4
]}

Tournamille, Christophe ^{[1
,2
,3
]}

Chami, Btissam ^{[1
]}

Pirenne, France ^{[1
,2
,3
,4
]}

机构：

[1] Etab Francais Sang EFS Ile de France, Creteil, France

[2] INSERM U955, Equipe Transfus & Malad Globule Rouge 2, Creteil, France

[3] Lab Excellence GR Ex, Creteil, France

[4] UPEC, Fac Med, IMRB, Creteil, France

来源：

TRANSFUSION MEDICINE AND HEMOTHERAPY | 2018年 / 45卷 / 04期

关键词：

Sickle cell disease; Transfusion medicine; Blood group genotyping; RH antigens; Partial antigens; HEMOLYTIC TRANSFUSION REACTION; ENCODES PARTIAL C; CLINICALLY RELEVANT; BLACK INDIVIDUALS; MOLECULAR-BASIS; RHD ALLELES; RHCE; ALLOIMMUNIZATION; PHENOTYPES; ANTIGEN;

D O I：

10.1159/000490858

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This review presents the French strategy for blood group genotyping in high-responder and newly diagnosed sickle cell disease (SCD) patients. In addition to FY, JK, and MNS genotyping, the RH blood group system is now explored in SCD patients in France. Molecular typing has been used for the deduction of partial RH2 (C) antigens since 2010, and the gradual implementation of systematic RHD and RHCE genotyping nationwide was initiated in late 2014. In our laboratory, 962 RH: 2 (C-positive) SCD patients have been tested since 2010, and 1,148 SCD patients of all RH phenotypes have been genotyped for clinically relevant alleles of RHD and RHCE since late 2014. (C) 2018 S. Karger GmbH, Freiburg

引用

页码：264 / 270

页数：7

共 47 条

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