Palladium-Catalyzed C-2 C-H Heteroarylation of Chiral Oxazolines: Diverse Synthesis of Chiral Oxazoline Ligands

被引：28

作者：

Xi, Tuo ^{[1
]}

Mei, Yuncai ^{[1
]}

Lu, Zhan ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, Hangzhou 310028, Zhejiang, Peoples R China

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 24期

关键词：

ASYMMETRIC CATALYSIS; HETEROAROMATIC-COMPOUNDS; DIRECT ARYLATION; BOND ACTIVATION; 1,1-DISUBSTITUTED ALKENES; ARYL ALKENES; HYDROBORATION; FUNCTIONALIZATION; VERSATILE; HYDROSILYLATION;

D O I：

10.1021/acs.orglett.5b03041

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A direct, efficient, and practical protocol to install a chiral Oxazoline unit onto aryl/heteroaryl rings via palladium-catalyzed C-H functionalization of 2-positions of oXazolines with a variety of halides using dppe as the ligand has been developed. Various chiral oxazdline ligands could be synthesized, even in a 10-g scale process. This protocol is a good supplement to traditional methods and for diverse synthesis of chiral oxazoline ligands.

引用

页码：5939 / 5941

页数：3

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