Network Medicine in Pathobiology

被引：51

作者：

Lee, Laurel Yong-Hwa ^{[1
]}

Loscalzo, Joseph ^{[1
]}

机构：

[1] Harvard Med Sch, Brigham & Womens Hosp, Boston, MA 02115 USA

来源：

AMERICAN JOURNAL OF PATHOLOGY | 2019年 / 189卷 / 07期

关键词：

POSTTRANSLATIONAL MODIFICATIONS; INTEGRATIVE ANALYSIS; PRECISION MEDICINE; WIDE ASSOCIATION; DISEASE; DISCOVERY; IDENTIFICATION; INFERENCE; PATHWAY; METABOLOMICS;

D O I：

10.1016/j.ajpath.2019.03.009

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The past decade has witnessed exponential growth in the generation of high-throughput human data across almost all known dimensions of biological systems. The discipline of network medicine has rapidly evolved in parallel, providing an unbiased, comprehensive biological framework through which to interrogate and integrate systematically these large-scale, multi-omic data to enhance our understanding of disease mechanisms and to design drugs that reflect a deep knowledge of molecular pathobiology. In this review, we discuss the key principles of network medicine and the human disease network and explore the latest applications of network medicine in this multi-omic era. We also highlight the current conceptual and technological challenges, which serve as exciting opportunities by which to improve and expand the network-based applications beyond the artificial boundaries of the current state of human pathobiology.

引用

页码：1311 / 1326

页数：16

共 134 条

[1]

Aibar S, 2017, NAT METHODS, V14, P1083, DOI [10.1038/nmeth.4463, 10.1038/NMETH.4463]

[2] A Network-Based Approach to Prioritize Results from Genome-Wide Association Studies [J].

Akula, Nirmala ;

Baranova, Ancha ;

Seto, Donald ;

Solka, Jeffrey ;

Nalls, Michael A. ;

Singleton, Andrew ;

Ferrucci, Luigi ;

Tanaka, Toshiko ;

Bandinelli, Stefania ;

Cho, Yoon Shin ;

Kim, Young Jin ;

Lee, Jong-Young ;

Han, Bok-Ghee ;

McMahon, Francis J. .

PLOS ONE, 2011, 6 (09)

[3] Error and attack tolerance of complex networks [J].

Albert, R ;

Jeong, H ;

Barabási, AL .

NATURE, 2000, 406 (6794) :378-382

[4] Robustness in bacterial chemotaxis [J].

Alon, U ;

Surette, MG ;

Barkai, N ;

Leibler, S .

NATURE, 1999, 397 (6715) :168-171

[5] The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes [J].

Altshuler, D ;

Hirschhorn, JN ;

Klannemark, M ;

Lindgren, CM ;

Vohl, MC ;

Nemesh, J ;

Lane, CR ;

Schaffner, SF ;

Bolk, S ;

Brewer, C ;

Tuomi, T ;

Gaudet, D ;

Hudson, TJ ;

Daly, M ;

Groop, L ;

Lander, ES .

NATURE GENETICS, 2000, 26 (01) :76-80

[6]

[Anonymous], 2017, Network Medicine: Complex Systems in Human Disease and Therapeutics

[7]

Arakawa Kazuharu, 2013, Methods Mol Biol, V985, P459, DOI 10.1007/978-1-62703-299-5_23

[8] Biological messiness vs. biological genius: Mechanistic aspects and roles of protein promiscuity [J].

Atkins, William M. .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2015, 151 :3-11

[9] Information encoded in a network of inflammation proteins predicts clinical outcome after myocardial infarction [J].

Azuaje, Francisco J. ;

Rodius, Sophie ;

Zhang, Lu ;

Devaux, Yvan ;

Wagner, Daniel R. .

BMC MEDICAL GENOMICS, 2011, 4

[10] Emergence of scaling in random networks [J].

Barabási, AL ;

Albert, R .

SCIENCE, 1999, 286 (5439) :509-512

← 1 2 3 4 5 6 7 8 9 10 →