A nonpeptidic agonist ligand of the human C5a receptor: Synthesis, binding affinity optimization and functional characterization.

被引：19

作者：

deLaszlo, SE ^{[1
]}

Allen, EE ^{[1
]}

Li, B ^{[1
]}

Ondeyka, D ^{[1
]}

Rivero, R ^{[1
]}

Malkowitz, L ^{[1
]}

Molineaux, C ^{[1
]}

Siciliano, SJ ^{[1
]}

Springer, MS ^{[1
]}

Greenlee, WJ ^{[1
]}

Mantlo, N ^{[1
]}

机构：

[1] MERCK RES LABS,DEPT IMMUNOL RES,RAHWAY,NJ 07065

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(96)00606-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The structural optimization for binding affinity and attempted modification of agonist function of a nonpeptide ligand of the human C5a receptor is described. (C) 1997, Elsevier Science Ltd.

引用

收藏

页码：213 / 218

页数：6

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