Shining Light on the Dark Side of Imaging: Excited State Absorption Enhancement of a Bis-styryl BODIPY Photoacoustic Contrast Agent

被引:87
作者
Frenette, Mathieu [1 ]
Hatamimoslehabadi, Maryam [2 ]
Bellinger-Buckley, Stephanie [1 ]
Laoui, Samir [2 ]
La, Jeffrey [2 ]
Bag, Seema [1 ]
Mallidi, Srivalleesha [3 ]
Hasan, Tayyaba [3 ]
Bouma, Brett [3 ]
Yeleswarapu, Chandra [2 ]
Rochford, Jonathan [1 ]
机构
[1] Univ Massachusetts, Dept Chem, Boston, MA 02125 USA
[2] Univ Massachusetts, Dept Phys, Boston, MA 02125 USA
[3] Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA
关键词
TRANSIENT ABSORPTION; IN-VIVO; BIOMEDICAL APPLICATIONS; INDOCYANINE GREEN; MICROSCOPY; NANOPARTICLES; TOMOGRAPHY; THERAPY;
D O I
10.1021/ja508600x
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A first approach toward understanding the targeted design of molecular photoacoustic contrast agents (MPACs) is presented. Optical and photoacoustic Z-scan spectroscopy was used to identify how nonlinear (excited-state) absorption contributes to enhancing the photoacoustic emission of the curcuminBF(2) and bis-styryl (MeOPh)(2)BODIPY dyes relative to Cy3.
引用
收藏
页码:15853 / 15856
页数:4
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