Circulating tumor-cell detection and capture using microfluidic devices

被引：108

作者：

Hajba, Laszlo ^{[1
]}

Guttman, Andras ^{[1
,2
]}

机构：

[1] Univ Pannonia, MTA PE Translat Glyc, MUKKI, Veszprem, Hungary

[2] Univ Debrecen, Horvath Lab Bioseparat Sci, H-4012 Debrecen, Hungary

来源：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2014年 / 59卷

关键词：

Cancer-therapy management; Circulating tumor cell (CTC); CTC capture; CTC detection; Dielectrophoresis; Early detection; Hydrodynamics; Metastases; Microfluidics; Nanotechnology; CANCER-PATIENTS; ON-CHIP; CONTINUOUS SEPARATION; MICROCAVITY ARRAY; BLOOD; SIZE; PARTICLES; DIELECTROPHORESIS; ELECTROMAGNETS; ENRICHMENT;

D O I：

10.1016/j.trac.2014.02.017

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Circulating tumor cells (CTCs) in the bloodstream are considered good indicators of the presence of a primary tumor or even metastases. CTC capture has great importance in early detection of cancer, especially in identifying novel therapeutic routes for cancer patients by finding personalized druggable targets for the pharmaceutical industry. Recent developments in microfluidics and nanotechnology improved the capabilities of CTC detection and capture, including purity, selectivity and throughput. This article covers the recent technological improvements in microfluidics-based CTC-capture methods utilizing the physical and biochemical properties of CTCs. We critically review the most promising hydrodynamic, dielectrophoretic and magnetic force-based microfluidic CTC-capture devices. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：9 / 16

页数：8

共 77 条

[1] Interdigitated comb-like electrodes for continuous separation of malignant cells from blood using dielectrophoresis [J].