Advances in bioluminescence imaging of live animal models

被引：126
作者：
Dothager, Robin S. [1 ,2 ]
Flentie, Kelly [1 ,2 ]
Moss, Britney [1 ,2 ]
Pan, Mei-Hsiu [1 ,2 ]
Kesarwala, Aparna [1 ,2 ]
Piwnica-Worms, David [1 ,2 ]
机构：
[1] Washington Univ, Sch Med, Edward Mallinckrodt Inst Radiol, Mol Imaging Ctr, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Dept Dev Biol, St Louis, MO 63110 USA
来源：
CURRENT OPINION IN BIOTECHNOLOGY | 2009年 / 20卷 / 01期
基金：
美国国家科学基金会;
关键词：
IN-VIVO; LIVING MICE; CELLS; TISSUE; ACTIVATION; MOUSE; TRAFFICKING; GENERATION; EXPRESSION; DYNAMICS;
D O I：
10.1016/j.copbio.2009.01.007
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Many of the obligate steps of physiology and disease are dynamic in time and space, and thus, end-point assays do not always provide a full understanding of these processes. Comprehensive understanding of the functional complexity of protein interactions and cell trafficking requires mapping of cellular and molecular function within complex systems over biologically relevant time scales. New approaches to bioluminescence imaging of cell migration, signaling pathways, drug action, and interacting protein partners in vivo allow the study of biology and disease within the context of living animals.
引用
收藏
页码：45 / 53
页数：9
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