Advances in bioluminescence imaging of live animal models

被引：125
作者：
Dothager, Robin S. [1 ,2 ]
Flentie, Kelly [1 ,2 ]
Moss, Britney [1 ,2 ]
Pan, Mei-Hsiu [1 ,2 ]
Kesarwala, Aparna [1 ,2 ]
Piwnica-Worms, David [1 ,2 ]
机构：
[1] Washington Univ, Sch Med, Edward Mallinckrodt Inst Radiol, Mol Imaging Ctr, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Dept Dev Biol, St Louis, MO 63110 USA
来源：
CURRENT OPINION IN BIOTECHNOLOGY | 2009年 / 20卷 / 01期
基金：
美国国家科学基金会;
关键词：
IN-VIVO; LIVING MICE; CELLS; TISSUE; ACTIVATION; MOUSE; TRAFFICKING; GENERATION; EXPRESSION; DYNAMICS;
D O I：
10.1016/j.copbio.2009.01.007
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Many of the obligate steps of physiology and disease are dynamic in time and space, and thus, end-point assays do not always provide a full understanding of these processes. Comprehensive understanding of the functional complexity of protein interactions and cell trafficking requires mapping of cellular and molecular function within complex systems over biologically relevant time scales. New approaches to bioluminescence imaging of cell migration, signaling pathways, drug action, and interacting protein partners in vivo allow the study of biology and disease within the context of living animals.
引用
收藏
页码：45 / 53
页数：9
相关论文
共 42 条
  • [1] Independent circadian oscillations of Period1 in specific brain areas in vivo and in vitro
    Abraham, U
    Prior, JL
    Granados-Fuentes, D
    Piwnica-Worms, DR
    Herzog, ED
    [J]. JOURNAL OF NEUROSCIENCE, 2005, 25 (38) : 8620 - 8626
  • [2] Prolonging islet allograft survival using in vivo bioluminescence imaging to guide timing of antilymphocyte serum treatment of rejection
    Chen, Xiaojuan
    Zhang, Xiaomin
    Larson, Courtney
    Xia, Guliang
    Kaufman, Dixon B.
    [J]. TRANSPLANTATION, 2008, 85 (09) : 1246 - 1252
  • [3] Tumor-targeting prodrug-activating bacteria for cancer therapy
    Cheng, C-M
    Lu, Y-L
    Chuang, K-H
    Hung, W-C
    Shiea, J.
    Su, Y-C
    Kao, C-H
    Chen, B-M
    Roffler, S.
    Cheng, T-L
    [J]. CANCER GENE THERAPY, 2008, 15 (06) : 393 - 401
  • [4] Advances in vivo bioluminescence imaging of gene expression
    Contag, CH
    Bachmann, MH
    [J]. ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, 2002, 4 : 235 - 260
  • [5] In vivo imaging of tissue eosinophilia and eosinopoietic responses to schistosome worms and eggs
    Davies, SJ
    Smith, SJ
    Lim, KC
    Zhang, HB
    Purchio, AF
    McKerrow, JH
    West, DB
    [J]. INTERNATIONAL JOURNAL FOR PARASITOLOGY, 2005, 35 (08) : 851 - 859
  • [6] Conjugated action of two species-specific invasion proteins for fetoplacental listeriosis
    Disson, Olivier
    Grayo, Solene
    Huillet, Eugenie
    Nikitas, Georgios
    Langa-Vives, Francina
    Dussurget, Olivier
    Ragon, Marie
    Le Monnier, Alban
    Babinet, Charles
    Cossart, Pascale
    Lecuit, Marc
    [J]. NATURE, 2008, 455 (7216) : 1114 - 1118
  • [7] Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK
    Galkin, Anna V.
    Melnick, Jonathan S.
    Kim, Sungjoon
    Hood, Tami L.
    Li, Nanxin
    Li, Lintong
    Xia, Gang
    Steensma, Ruo
    Chopiuk, Greg
    Jiang, Jiqing
    Wan, Yongqin
    Ding, Peter
    Liu, Yi
    Sun, Fangxian
    Schultz, Peter G.
    Gray, Nathanael S.
    Warmuth, Markus
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (01) : 270 - 275
  • [8] Primary involvement of pharynx and Peyer's patch in inhalational and intestinal anthrax
    Glomski, Ian J.
    Piris-Gimenez, Alejandro
    Huerre, Michel
    Mock, Michele
    Goossens, Pierre L.
    [J]. PLOS PATHOGENS, 2007, 3 (06) : 699 - 708
  • [9] Real-time imaging of ligand-induced IKK activation in intact cells and in living mice
    Gross, S
    Piwnica-Worms, D
    [J]. NATURE METHODS, 2005, 2 (08) : 607 - 614
  • [10] Spying on cancer: Molecular imaging in vivo with genetically encoded reporters
    Gross, S
    Piwnica-Worms, D
    [J]. CANCER CELL, 2005, 7 (01) : 5 - 15
12345