Baseline characteristics of the 4011 patients recruited into the 'Efficacy of Nitric Oxide in Stroke' (ENOS) trial

被引:17
作者
Bath, Philip M. W. [1 ]
Adami, Alessandro [2 ]
Bereczki, Daniel [3 ]
Berge, Eivind [4 ]
Beridze, Maia [5 ]
Cala, Lesley [6 ]
Casado, Ana [7 ]
Caso, Valeria [8 ]
Chang, Hui Meng [9 ]
Christensen, Hanne [10 ]
Collins, Ronan [11 ]
Czlonkowska, Anna [12 ]
Dineen, Robert A. [13 ]
El Etribi, Anwar [14 ]
Ghani, Abdul Rahman [15 ]
Gommans, John [16 ]
Koumellis, Panos [17 ]
Laska, Ann Charlotte [18 ]
Lees, Kennedy R. [19 ]
Navarro, Jose [20 ]
Ntaios, George [21 ]
Ozturk, Serefnur [22 ]
Phillips, Stephen [23 ]
Pocock, Stuart [24 ]
Prasad, Kameshwar [25 ]
Scutt, Polly [1 ]
de Silva, H. Asita [26 ]
Szatmari, Szabolcs [27 ]
Diez-Tejedor, Exuperio [28 ]
Utton, Sally [1 ]
Wang, Yong-Jun [29 ]
Wardlaw, Joanna M. [7 ]
Whynes, David [30 ]
Wong, Lawrence [31 ]
Woodhouse, Lisa [1 ]
Sprigg, Nikola [1 ]
机构
[1] Univ Nottingham, Div Clin Neurosci, Stroke Trials Unit, Nottingham NG5 1PB, England
[2] Osped Sacro Cuore, Dept Neurol, Stroke Ctr, I-37024 Verona, Italy
[3] Semmelweis Univ, Dept Neurol, H-1085 Budapest, Hungary
[4] Oslo Univ Hosp, Dept Internal Med, NO-0407 Oslo, Norway
[5] Hosp War Vet, Tbilisi, Georgia
[6] Univ Western Australia, Sch Pathol & Lab Med, Crawley, WA 6009, Australia
[7] Univ Edinburgh, Ctr Clin Brain Sci, Edinburgh EH4 2XU, Midlothian, Scotland
[8] Univ Perugia, Santa Maria Misericordia Hosp, I-06126 Perugia, Italy
[9] Singapore Gen Hosp, Natl Inst Neurosci, Singapore 169608, Singapore
[10] Univ Copenhagen, Bispebjerg Hosp, DK-2400 Copenhagen, Denmark
[11] Adelaide & Meath Hosp, Dublin 24, Ireland
[12] Inst Psychiat & Neurol, Dept Neurol 2, PL-02957 Warsaw, Poland
[13] Univ Nottingham, Div Clin Neurosci, Radiol Sci Res Grp, Nottingham NG7 2UH, England
[14] Ain Shams Univ, Cairo, Egypt
[15] Hosp Univ Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia
[16] Hawkes Bay Hosp, Hastings 4156, New Zealand
[17] Princess Royal Hosp, Hurstwood Pk Neurosci Ctr, Haywards Heath RH16 4EX, W Sussex, England
[18] Karolinska Inst, Danderyd Hosp, Dept Clin Sci, SE-18288 Stockholm, Sweden
[19] Univ Glasgow, Western Infirm, Inst Cardiovasc & Med Sci, Glasgow G11 6NT, Lanark, Scotland
[20] Jose R Reyes Mem Med Ctr, Sta Cruz 1003, Metro Manila, Philippines
[21] Univ Thessaly, Larissa Univ Hosp, Dept Med, Biopolis 41110, Larissa, Greece
[22] Selcuk Univ, Sch Med, Dept Neurol, Selcuklu, Konya, Turkey
[23] Queen Elizabeth 2 Hlth Sci Ctr, Div Neurol, Halifax Infirm, Halifax, NS B3H 3A7, Canada
[24] Univ London London Sch Hyg & Trop Med, London WC1E 7HT, England
[25] All India Inst Med Sci, Ctr Neurosci, New Delhi 110029, India
[26] Univ Kelaniya, Fac Med, Clin Trials Unit, Ragama, Sri Lanka
[27] Clin Cty Emergency Hosp Tirgu Mures, Targu Mures 540136, Romania
[28] Autonomous Univ Madrid, IdiPAZ Hlth Res Inst, La Paz Univ Hosp, Madrid, Spain
[29] Tian Tan Hosp, Beijing 100050, Peoples R China
[30] Univ Nottingham, Sch Econ, Nottingham NG7 2RD, England
[31] Prince Wales Hosp, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China
基金
英国医学研究理事会;
关键词
acute stroke; antihypertensive drugs; blood pressure; glyceryl trinitrate; nitric oxide; randomized controlled trial; TRANSDERMAL GLYCERYL TRINITRATE; ACUTE ISCHEMIC-STROKE; BLOOD-PRESSURE; SCALE;
D O I
10.1111/ijs.12308
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background High blood pressure is common in acute stroke and associated with a worse functional outcome. Many patients who present with acute stroke are taking prescribed antihypertensive therapy before their stroke. Aims ENOS tested whether lowering blood pressure and continuing pre-stroke antihypertensive therapy are each safe and effective. Methods This study is an international multi-centre prospective randomized single-blind blinded-endpoint parallel-group partial-factorial controlled trial of transdermal glyceryl trinitrate (a nitric oxide donor, given for seven-days) vs. no glyceryl trinitrate, and of continuing vs. stopping (temporarily for seven-days) pre-stroke antihypertensive drugs if relevant, in patients with acute ischaemic stroke or intracerebral haemorrhage and high systolic blood pressure (140-220 mmHg). Results Recruitment ran from July 2001 to October 2013. Four thousand eleven patients [2097 (52.3%) in the continue/stop arm] were recruited from 173 sites across 23 countries in 5 continents (Asia 14%, Continental Europe 16%, UK 64%). Baseline characteristics include: mean age 70 (standard deviation 12) years; male 57%; mean time from stroke to recruitment 26 (13) h; mean severity (Scandinavian Stroke Scale) 34 (13) of 58; mean blood pressure 167 (19)/90 (13) mmHg; ischaemic stroke 83%; and intracerebral haemorrhage 16%. The main trial results will be presented in May 2014. The results will also be presented in updated Cochrane systematic reviews and included in individual patient data meta-analyses of all relevant randomized controlled trials. Conclusion ENOS is a large completed international trial of blood pressure management in acute stroke and includes patients representative of many stroke services worldwide.
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收藏
页码:711 / 720
页数:10
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