Essential Roles of Epithelial Bone Morphogenetic Protein Signaling During Prostatic Development

被引:9
|
作者
Omori, Akiko [1 ]
Miyagawa, Shinichi [2 ]
Ogino, Yukiko [2 ]
Harada, Masayo [3 ]
Ishii, Kenichiro [4 ]
Sugimura, Yoshiki [5 ]
Ogino, Hajime [6 ]
Nakagata, Naomi [7 ]
Yamada, Gen [1 ]
机构
[1] Wakayama Med Univ, Dept Dev Genet, Inst Adv Med, Wakayama 6418509, Japan
[2] Natl Inst Nat Sci, Natl Inst Basic Biol, Okazaki Inst Integrat Biosci, Okazaki, Aichi 4448787, Japan
[3] Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Clin Anat, Tokyo 1138591, Japan
[4] Mie Univ, Grad Sch Med, Dept Oncol Pathol, Tsu, Mie 5148507, Japan
[5] Mie Univ, Grad Sch Med, Tsu, Mie 5148507, Japan
[6] Nagahama Inst Biosci & Technol, Dept Anim Biosci, Nagahama, Shiga 5260829, Japan
[7] Kumamoto Univ, Ctr Anim Resources & Dev, Div Reprod Engn, Kumamoto 8600811, Japan
关键词
BRANCHING MORPHOGENESIS; GLAND DEVELOPMENT; MOUSE PROSTATE; STEM-CELLS; SEXUAL DEVELOPMENT; BETA-CATENIN; TARGET GENES; NKX3.1; CANCER; DIFFERENTIATION;
D O I
10.1210/en.2013-2054
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Prostate is a male sex-accessory organ. The prostatic epithelia consist primarily of basal and luminal cells that differentiate from embryonic urogenital sinus epithelia. Prostate tumors are believed to originate in the basal and luminal cells. However, factors that promote normal epithelial differentiation have not been well elucidated, particularly for bone morphogenetic protein (Bmp) signaling. This study shows that Bmp signaling prominently increases during prostatic differentiation in the luminal epithelia, which is monitored by the expression of phosphorylated Smad1/5/8. To elucidate the mechanism of epithelial differentiation and the function of Bmp signaling during prostatic development, conditional male mutant mouse analysis for the epithelial-specific Bmp receptor 1a (Bmpr1a) was performed. We demonstrate that Bmp signaling is indispensable for luminal cell maturation, which regulates basal cell proliferation. Expression of the prostatic epithelial regulatory gene Nkx3.1 was significantly reduced in the Bmpr1a mutants. These results indicate that Bmp signaling is a key factor for prostatic epithelial differentiation, possibly by controlling the prostatic regulatory gene Nkx3.1.
引用
收藏
页码:2534 / 2544
页数:11
相关论文
共 50 条
  • [31] A role for bone morphogenetic protein-4 in adipocyte development
    Bowers, Robert R.
    Lane, M. Daniel
    CELL CYCLE, 2007, 6 (04) : 385 - 389
  • [32] Loss of mesenchymal bone morphogenetic protein signaling leads to development of reactive stroma and initiation of the gastric neoplastic cascade
    Roy, Sebastien A. B.
    Allaire, Joannie M.
    Ouellet, Camille
    Maloum-Rami, Faiza
    Pomerleau, Veronique
    Lemieux, Etienne
    Babeu, Jean-Philippe
    Rousseau, Jasmin
    Paquet, Marilene
    Garde-Granger, Perrine
    Boudreau, Francois
    Perreault, Nathalie
    SCIENTIFIC REPORTS, 2016, 6
  • [33] Repulsive guidance molecule b inhibits renal cyst development through the bone morphogenetic protein signaling pathway
    Liu, Jiangfeng
    Wang, Weiling
    Liu, Ming
    Su, Limin
    Zhou, Hong
    Xia, Yin
    Ran, Jianhua
    Lin, Herbert Y.
    Yang, Baoxue
    CELLULAR SIGNALLING, 2016, 28 (12) : 1842 - 1851
  • [34] Loss of bone morphogenetic protein signaling in fibroblasts results in CXCL12-driven serrated polyp development
    Ouahoud, Sarah
    Westendorp, Barbara Florien
    Voorneveld, Philip Willen
    Abudukelimu, Subinuer
    Koelink, Pim Johan
    Garcia, Elena Pascual
    Buuren, Jessica Flora Isabella
    Harryvan, Tom Jacob
    Lenos, Kristiaan Jan
    van Wezel, Tom
    Offerhaus, Johan Arnold
    Farina-Sarasqueta, Arantza
    Crobach, Stijn
    Slingerland, Marije
    Hardwick, James Christopher Henry
    Hawinkels, Lukas Jacobus Antonius Christiaan
    JOURNAL OF GASTROENTEROLOGY, 2023, 58 (01) : 25 - 43
  • [35] Regulation of Prostate Development and Benign Prostatic Hyperplasia by Autocrine Cholinergic Signaling via Maintaining the Epithelial Progenitor Cells in Proliferating Status
    Wang, Naitao
    Dong, Bai-Jun
    Quan, Yizhou
    Chen, Qianqian
    Chu, Mingliang
    Xu, Jin
    Xue, Wei
    Huang, Yi-Ran
    Yang, Ru
    Gao, Wei-Qiang
    STEM CELL REPORTS, 2016, 6 (05): : 668 - 678
  • [36] Chondrocyte-Specific MicroRNA-140 Regulates Endochondral Bone Development and Targets Dnpep To Modulate Bone Morphogenetic Protein Signaling
    Nakamura, Yukio
    Inloes, Jennifer B.
    Katagiri, Takenobu
    Kobayashi, Tatsuya
    MOLECULAR AND CELLULAR BIOLOGY, 2011, 31 (14) : 3019 - 3028
  • [37] Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development
    Geng, Yan
    Dong, Yingying
    Yu, Mingyan
    Zhang, Long
    Yan, Xiaohua
    Sun, Jingxia
    Qiao, Long
    Geng, Huixia
    Nakajima, Masahiro
    Furuichi, Tatsuya
    Ikegawa, Shiro
    Gao, Xiang
    Chen, Ye-Guang
    Jiang, Dianhua
    Ning, Wen
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (17) : 7058 - 7063
  • [38] Role of miR-17 Family in the Negative Feedback Loop of Bone Morphogenetic Protein Signaling in Neuron
    Sun, Qi
    Mao, Susu
    Li, Hanqin
    Zen, Ke
    Zhang, Chen-Yu
    Li, Liang
    PLOS ONE, 2013, 8 (12):
  • [39] Role of RUNX3 in Bone Morphogenetic Protein Signaling in Colorectal Cancer
    Lee, Cecilia Wei Lin
    Ito, Kosei
    Ito, Yoshiaki
    CANCER RESEARCH, 2010, 70 (10) : 4243 - 4252
  • [40] Bone morphogenetic protein signaling transcription factor (SMAD) function in granulosa cells
    Pangas, Stephanie A.
    MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2012, 356 (1-2) : 40 - 47