The author offers advice to faculty, students, and staff who become involved in issues of research misconduct, whether as the accuser or as the accused. After reviewing the different definitions of research misconduct used by various authorities and discussing other kinds and degrees of misconduct, he provides information to those who suspect research misconduct, to help them identify their responsibilities and the risks involved: he makes it clear that an accusation of research fraud or other misconduct has serious consequences for all parties. The author then discusses how to pursue concerns about improper research practices, emphasizing a nonconfrontational approach and the use of proper channels for reporting. He explains the process of a formal review including characteristic institutional responses; the role of the Office of Research Integrity; and when to seek the advice of an attorney. He argues that education is clearly preferable to denunciation as a way to improve scientists' ethics and practices. The author then gives similarly detailed advice to the accused, including a caution not to take criticism of methods or results as an accusation of fraud. He discusses the significances of the two stages of review of an allegation of misconduct, with practical advice for cooperative participation in any review; use of legal counsel; the importance of avoiding retaliation; information about due process and material evidence; the impact of a formal investigation; peer standards for evaluating misconduct; and the unavoidable discomfort that the accused will experience during the lengthy process. He advises that practicing good science is the first step in avoiding this unpleasant experience.