Meta-analysis of the differentially expressed breast cancer-related microRNA expression profiles

被引：6
作者：
Wu, J. [1 ]
Lu, P. [2 ]
Yang, T. [2 ]
Wang, L. [3 ]
机构：
[1] Zhengzhou Univ, Affiliated Hosp 2, Breast Canc Diag & Treatment Ctr Henan, Zhengzhou 450052, Peoples R China
[2] Zhengzhou Univ, Gastrointestinal Surg Dept, Affiliated Hosp 2, Zhengzhou 450052, Peoples R China
[3] Zhengzhou Univ, Dept Resp Med, Affiliated Hosp 2, Zhengzhou 450052, Peoples R China
来源：
JOURNAL OF OBSTETRICS AND GYNAECOLOGY | 2014年 / 34卷 / 07期
关键词：
Breast cancer; differentially expressed miRNA; meta-analysis; signalling pathway; WNT/BETA-CATENIN PATHWAY; GENE-EXPRESSION; CELL POLARITY; IDENTIFICATION; PROLIFERATION; PREDICTION; BIOMARKERS; NISCHARIN; RECEPTOR; MARKER;
D O I：
10.3109/01443615.2014.920782
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
MicroRNAs (miRNAs), as non-coding RNA molecules, play an important role in regulating gene expression in cancer development. Meta-analysis was used to screen overlapping differentially expressed miRNAs (DEmiRNAs) in three studies. The miRanda was used to identify target genes related to overlapping DEmiRNAs. These Gene Ontology (GO) and Encyclopaedia of Genes and Genomes (KEGG) database were applied to further predict the function of these target genes. As a result, we obtained seven overlapping miRNAs and six significantly over-represented GO terms closely related to breast cancer. After KEGG pathways analysis, a total of seven key target genes were involved in the Wnt signalling pathway (p = 0.0002). Our findings from this study suggest that the altered levels of miRNAs might have great potential to serve as novel, non-invasive biomarkers for early detection of breast cancer.
引用
收藏
页码：630 / 633
页数：4
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