Role of MicroRNAs in B Cell Leukemias and Lymphomas

被引：9

作者：

Schmidt, A. ^{[1
]}

Kueppers, R. ^{[1
]}

机构：

[1] Univ Duisburg Essen, Fac Med, Inst Cell Biol Canc Res, D-45122 Essen, Germany

来源：

CURRENT MOLECULAR MEDICINE | 2014年 / 14卷 / 05期

关键词：

B cells; Hodgkin lymphoma; leukemia; lymphoma; MicroRNA; CHRONIC LYMPHOCYTIC-LEUKEMIA; MARGINAL ZONE LYMPHOMA; ENDOTHELIAL GROWTH-FACTOR; HODGKIN/REED-STERNBERG CELLS; INDUCED CYTIDINE DEAMINASE; VIRUS-INDUCED LYMPHOMAS; EPSTEIN-BARR-VIRUS; V-H GENES; MANTLE-CELL; GERMINAL CENTER;

D O I：

10.2174/1566524014666140603095414

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

MicroRNAs (miRNAs) are a class of small (18 similar to 25 nucleotides long) non-coding RNAs that regulate gene expression on the post-transcriptional level. During the last decade, the field of miRNA research has been exponentially expanding, revealing the widespread role of these molecules in numerous biological processes. Aberrant miRNA expression has been documented in multiple haematologic malignancies, including B cell lymphomas. There is compelling evidence that miRNAs can function as oncogenes or tumor suppressor genes in lymphoid malignancies. In this review, we recapitulate the current knowledge of miRNA expression in B cell malignancies and discuss the accumulating evidence for a major role of miRNA deregulation in the development of B cell-derived lymphoid tumors.

引用

页码：580 / 597

页数：18

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